CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit

• Cat.No.: Kit-1713
• Product Overview: B7-2 (CD86) signaling through CTLA4(CD152) has been shown to inhibit T cell activation. This co-inhibitory pathway can be overactive in many tumors, enabling cancers to escape the host"s immune system. CTLA4-blocking antibodies, including Ipilimumab (Yervoy) and Tremelimumab, have shown clinical efficacy in treating cancer.

Specification

• Size: 96 reactions
• Applications: This kit is useful for screening for inhibitors of CTLA4 binding to B7-2.
• Storage: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival