Goat Anti-Human GALR2 Polyclonal Antibody

Cat.No.

CPBT-52763GH

Product Overview

Goat Polyclonal antibody to Human GALR2.

Antigen Description

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

Isotype

IgG

Immunogen

Synthetic peptide: C-RYPLHSRELRTPRN, corresponding to internal sequence amino acids 128-141 of Human GALR2

Host

Goat

Species

Human

Specificity

Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

Formulation

Liquid

Purity Detail

Immunogen affinity purified

Applications

WB

Storage buffer

Preservative: 0.02% Sodium AzideConstituents: 0.5% BSA, Tris saline, pH 7.3

Storage

Shipped at 4^oC. Upon delivery aliquot and store at -20^oC or -80^oC. Avoid repeated freeze / thaw cycles.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Antigen Gene Information