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Cat.No.
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CPBT-54027RH
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Product Overview
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Rabbit Polyclonal antibody to Human GRIK2.
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Antigen Description
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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
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Isotype
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IgG
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Immunogen
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Synthetic peptide derived from N terminaldomain of human Glutamate Receptor Ionotropic 6 (GRIK2).
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Host
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Rabbit
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Species
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Human
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Formulation
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Liquid
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Purity Detail
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Whole antiserum
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Applications
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IHC-P, ICC/IF, WB
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Storage buffer
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Preservative: NoneConstituents: Whole serum
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
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Antigen Gene Information
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Gene Name
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GRIK2 glutamate receptor, ionotropic, kainate 2 [ Homo sapiens ]
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Official Symbol
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GRIK2
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Synonyms
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GRIK2; glutamate receptor, ionotropic, kainate 2; GLUR6; glutamate receptor, ionotropic kainate 2; MRT6; EAA4; Excitatory amino acid receptor 4; GLR 6; GLR6; GLUR 6; GLUR6; Glutamate receptor 6; Glutamate receptor ionotropic kainate 2; GRIK 2; GRIK2 protein; gluR-6; bA487F5.1; OTTHUMP00000017949; OTTHUMP00000017950; OTTHUMP00000017951; glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; excitatory amino acid receptor 4; EAA4; GLR6; GLUK6;
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GeneID
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2898
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mRNA Refseq
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NM_001166247
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Protein Refseq
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NP_001159719
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MIM
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138244
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Uniprot ID
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Q13002
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Chromosome Location
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6q16.3-q21
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Pathway
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Activation of Ca-permeable Kainate Receptor, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Activation of Na-permeable Kainate Receptors, organism-specific biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem;
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Function
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PDZ domain binding; extracellular-glutamate-gated ion channel activity; ion channel activity; kainate selective glutamate receptor activity; protein homodimerization activity;
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Download Datasheet:
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