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Recombinant Human Rho Family GTPase 3, His-tagged

Cat.No. : RND3-2748H
Product Overview : Recombinant human RND3 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW =29.2kDa (261aa) confirmed by MALDI-TOF.
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Cat. No. : RND3-2748H
Description : Rho-related GTP-binding protein RhoE, also known as RND3, is a small GTPase of the Ras superfamily that regulate the organization of the actin cytoskeleton in response to extracellular growth factors. RND3 activity leads to a decrease in stress fibers and increased cell migration, at least in part through regulation of the Rho-dependent kinase ROCK1. Also, RND3 has been implicated in inhibition of DNA-damage induced apoptosis and cell cycle arrest.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS C
Purity : > 90% by SDS – PAGE.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 40% glycerol, 1mM EDTA, 0.1M NaCl.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : RND3 Rho family GTPase 3 [ Homo sapiens ]
Synonyms : RND3; Rho family GTPase 3; ARHE; Rho8; RhoE; memB; rho-related GTP-binding protein RhoE; protein MemB; OTTHUMP00000162685; OTTHUMP00000204380; OTTHUMP00000204381; small GTP binding protein Rho8; ras homolog gene family, member E; rho-related GTP-binding protein Rho8
Gene ID : 390
mRNA Refseq : NM_005168
Protein Refseq : NP_005159
MIM : 602924
UniProt ID : P61587
Chromosome Location : 2q23.3
Function : GTP binding; GTPase activity; nucleotide binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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