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Cat.No.
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CPBT-56412RH
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Product Overview
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Rabbit Polyclonal antibody to Human PDCD4.
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Antigen Description
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This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
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Isotype
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IgG
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Immunogen
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A synthetic peptide corresponding to amino acids near the carboxyl terminus of human PDCD4 protein
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Host
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Rabbit
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Species
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Human
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Specificity
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Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
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Formulation
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Liquid
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Purity Detail
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Immunogen affinity purified
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Applications
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WB, ELISA, IHC-P
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Storage buffer
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Preservative: 0.01% Sodium AzideConstituents: 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7.2
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
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Sequence similarities
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Belongs to the PDCD4 family.Contains 2 MI domains.
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Antigen Gene Information
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Gene Name
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PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) [ Homo sapiens ]
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Official Symbol
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PDCD4
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Synonyms
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PDCD4; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; H731; nuclear antigen H731; Death up-regulated gene protein; Dug; H731; Ma3; MGC33046; MGC33047; Neoplastic transformation inhibitor; Neoplastic transformation inhibitor protein; Nuclear antigen H731; Nuclear antigen H731 like; Nuclear antigen H731 like protein; Nuclear antigen H731-like; PDCD 4; Pdcd4; PDCD4_HUMAN; Programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor); Programmed cell death protein 4; Protein 197/15a; Protein MA-3; RP11 348N5.4; Tis; Topoisomerase-inhibitor suppressed protein; protein 197/15a; neoplastic transformation inhibitor protein;
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GeneID
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27250
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mRNA Refseq
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NM_001199492
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Protein Refseq
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NP_001186421
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MIM
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608610
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Uniprot ID
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Q53EL6
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Chromosome Location
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10q24
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Pathway
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mTOR signaling pathway, organism-specific biosystem;
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Function
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RNA binding; binding; protein binding;
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Download Datasheet:
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