Mouse Anti-Human Placental Alkaline Phosphatase Monoclonal Antibody (Placenta)
Cat.No. : | CAB-921RH |
- Specification
- Gene Information
- Related Products
Cat. No. : | CPB-921MH |
Specificity : | Human Placental Alkaline Phosphatase |
Host : | Mouse |
Clonality : | Monoclonal |
Positive Control : | Placenta |
Staining Pattern : | Cytoplasm |
Specificity Note : | The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer |
Applications : | Formalin-fixed paraffin-embedded tissue, or IHC frozen sections. No antigen retrieval necessary. |
Recommended Usage : | IHC test, research use only.Incubate with samples at RT for 60min or at 4℃ overnight. |
Storage : | 2-8℃ for 12 months. |
Unit : | Can be packed on the basis of your request. |
Gene Name : | ALPP alkaline phosphatase, placental (Regan isozyme) [ Homo sapiens ] |
Synonyms : | ALPP; alkaline phosphatase, placental (Regan isozyme); ALP; PALP; PLAP; FLJ61142; Alkaline phosphatase, placental type; PLAP-1; Alkaline phosphatase Regan isozyme; EC 3.1.3.1; glycerophosphatase; placental alkaline phosphatase; alkaline phosphomonoesterase |
Gene ID : | 250 |
mRNA Refseq : | NM_001632 |
Protein Refseq : | NP_001623 |
MIM : | 171800 |
UniProt ID : | P05187 |
Chromosome Location : | 2q37 |
Pathway : | Folate biosynthesis; Metabolic pathways; gamma-Hexachlorocyclohexane degradation |
Function : | alkaline phosphatase activity; hydrolase activity; magnesium ion binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
ALPP-124H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-2558H | Recombinant Human ALPP protein(31-500 aa), C-His-tagged | +Inquiry |
ALPP-125H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-329H | Recombinant Human ALPP Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPP-302H | Recombinant Human ALPP Protein, His tagged | +Inquiry |
◆ Native Protein | ||
ALPP-8347H | Native Human ALPP | +Inquiry |
ALPP-8005H | Native Human Placental Alkaline Phosphatase | +Inquiry |
◆ Lysates | ||
ALPP-8893HCL | Recombinant Human ALPP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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