Catalog # or name ...
Rabbit Polyclonal antibody to Human AANAT.
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synthetic peptide: CQRRHT(p)LPAS.Immunizing phosphopeptide corresponds to N-terminal amino acid residues 24-33 of mouse AA-NAT.This sequence is completely conserved between mouse, rat, and human AA-NAT protein.
Immunogen affinity purified
PBS, 1 mg/ml BSA and 0.05% sodium azide
Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
Antigen Gene Information
AANAT aralkylamine N-acetyltransferase [ Homo sapiens ]
AANAT; aralkylamine N-acetyltransferase; serotonin N-acetyltransferase; AANAT; Arylalkylamine N acetyltransferase; SNAT; serotonin acetylase; arylalkylamine N-acetyltransferase; DSPS; SNAT;
Amine-derived hormones, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Melatonin biosynthesis, tryptophan => serotonin => melatonin, organism-specific biosystem;
aralkylamine N-acetyltransferase activity; arylamine N-acetyltransferase activity; transferase activity, transferring acyl groups;
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