Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged
Cat.No. : | MAPK8-554H |
Product Overview : | Recombinant Human JNK1-β1/MAPK8 (K55M) (a.a.2-383) with N-terminal GST tag was expressed inE. coli. MW = 70 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | MAPK8-554H |
Description : | JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction. JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity. |
Source : | Escherichia Coli. |
Application : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Purity : | ≥85%. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT. |
Stability : | >12 months at -80°C. |
Gene Name : | MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens ] |
Synonyms : | mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; MAPK8; JNK-46; MAPK 8; MAP kinase 8; protein kinase JNK1; JUN N-terminal kinase; JNK1 beta protein kinase; JNK1 alpha protein kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase JNK1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; Stress-activated protein kinase JNK1; EC 2.7.11.24; OTTHUMP00000019552 |
Gene ID : | 5599 |
mRNA Refseq : | NM_002750.2 |
Protein Refseq : | NP_002741.1 |
MIM : | 601158 |
UniProt ID : | P45983 |
Chromosome Location : | 10q11.22 |
Pathway : | Adipocytokine signaling pathway; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; Fc epsilon RI signaling pathway; Focal adhesion; GnRH signaling pathway; Insulin signaling pathway; MAPK signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Pancreatic cancer; Pathways in cancer; Progesterone-mediated oocyte maturation; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus; Wnt signaling pathway |
Function : | ATP binding; JUN kinase activity; MAP kinase activity; kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
Mapk8-3945M | Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged | +Inquiry |
MAPK8-3435H | Recombinant Human MAPK8 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPK8-1136H | Recombinant Human MAPK8 Protein (S2-E364), Tag Free | +Inquiry |
MAPK8-1137H | Recombinant Human MAPK8 Protein (S2-E364), His tagged | +Inquiry |
MAPK8-2420H | Recombinant Human MAPK8 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MAPK8-4488HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
MAPK8-4489HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.
Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.
MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.
MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.
MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.
Customer Reviews (3)
Write a reviewI am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.
By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.
the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.
Ask a Question for All MAPK8 Products
Required fields are marked with *
My Review for All MAPK8 Products
Required fields are marked with *
Inquiry Basket