Recombinant Human Poly (ADP-ribose) Polymerase 1
Cat.No. : | PARP1-496H |
Product Overview : | Recombinant Human PARP1 protein was expressed inE.coliand purified by using conventional chromatography techniques, 39.6 kDa (354aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | PARP1-496H |
Description : | PARP1 is a nuclear DNA-binding zinc finger protein which can exist as a homo- or hetero-dimer, and is strongly activated by DNA strand breaks. This protein involved in chromatin architecture and DNA metabolism, and participates in protein modification to enhance or repress transcription. PARP1 also plays a role in other cellular processes, including cell proliferation and differentiation. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADPribosyl)ation contributes to the efficient maintenance of genome integrity. |
Source : | E.coli. |
Sequences Of Amino Acids : | MKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK LSKRQIQAAY SILSEVQQAV SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KAEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE REGECQRYKP FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW. |
Formulation : | Liquid. In 20mM Tris buffer(pH 8.0) containing 10% glycerol 1mM DTT. |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Base excision repair |
Gene Name : | PARP1 poly (ADP-ribose) polymerase 1 [ Homo sapiens ] |
Synonyms : | PARP1; poly (ADP-ribose) polymerase 1; PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1; poly (ADP-ribose) polymerase family, member 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1; EC 2.4.2.30 |
Gene ID : | 142 |
mRNA Refseq : | NM_001618 |
Protein Refseq : | NP_001609 |
MIM : | 173870 |
UniProt ID : | P09874 |
Chromosome Location : | 1q41-q42 |
Function : | DNA binding; NAD or NADH binding; NAD+ ADP-ribosyltransferase activity; identical protein binding; metal ion binding; protein N-terminus binding; protein binding; transcription factor binding; transferase activity, transferring glycosyl groups; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
ZNF101-434H | Recombinant Human PARP1 Protein, MYC/DDK-tagged | +Inquiry |
PARP1-1531H | Recombinant Human PARP1 Protein, His-tagged | +Inquiry |
PARP1-2615H | Recombinant Human PARP1 protein(61-370 aa), C-His-tagged | +Inquiry |
PARP1-640H | Recombinant Human PARP1 Protein, His-tagged | +Inquiry |
PARP1-431H | Recombinant Human PARP1 Protein, FLAG/Avi-tagged | +Inquiry |
◆ Lysates | ||
PARP1-710HCL | Recombinant Human PARP1 cell lysate | +Inquiry |
PARP1-514MCL | Recombinant Mouse PARP1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1794 | PARP1 Colorimetric Assay Kit | +Inquiry |
Kit-1792 | PARP1 Chemiluminescent Assay Kit | +Inquiry |
Kit-1793 | PARP1 Chemiluminescent Assay Kit (384-well) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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