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Cat. No.
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CSF3-P034H
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Product Overview
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Recombinant Human CSF3 is produced in E. coli and theresultant protein is 175 Aa. MW=18.8 KDa.
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Description
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PEGylated (at Nterminus) form of human CSF3 (Granulocyte colony stimulating factor), 175residues, produced from E. coli via bacterial fermentation.
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Background
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The protein encoded by this gene is acytokine that controls the production, differentiation, and function ofgranulocytes. The active protein is found extracellularly. Alternativelyspliced transcript variants have been described for this gene. The expressionproduct is the active ingredient of Neulasta,Granulokine, Granocyte and Neupogen.
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Purity
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>95%
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Source
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E. coli
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Species
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Human
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Endotoxin
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< 1.0 EU per μg of the protein
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Sequences of aminoacids
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MTPLGPASSLPQSFLLKCLEQVRKIQGDGAALQEKLCATYKLCHPEELVLLGHSLGIPWAPLSSCPSQAL
QLAGCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEELGMAPALQPTQGAMPA
FASAFQRRAGGVLVASHLQSFLEVSYRVLRHLAQP
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CAS number
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208265-92-3
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Storage
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Can be stored at +4oC short term (1-2weeks). For long term storage, aliquot and store at -20oC or -70oC. Avoidrepeated freezing and thawing cycles.
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Gene Information
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Gene Name
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CSF3colony stimulating factor 3 (granulocyte) [ Homo sapiens ]
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Official Symbol
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CSF3
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Synonyms
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CSF3; colonystimulating factor 3 (granulocyte); G-CSF; Granulocyte colony-stimulatingfactor precursor; Lenograstim; Pluripoietin; GCSF; CSF3OS; C17orf33;granulocyte colony-stimulating factor; filgrastim; chromosome 17 open readingframe 33; granulocyte colony stimulating factor; MGC45931;OTTHUMP00000164325; OTTHUMP00000164326; OTTHUMP00000164327;OTTHUMP00000164328
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GeneID
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1440
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mRNA Refseq
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NM_172219
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Protein Refseq
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NP_757373
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MIM
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138970
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UniProt ID
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P09919
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Chromosome Location
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17q11.2-q12
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Pathway
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Cytokine-cytokinereceptor interaction; Cytokines and Inflammatory Response; Hematopoietic celllineage; Jak-STAT signaling pathway; Malaria
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Function
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cytokine activity;enzyme binding; granulocyte colony-stimulating factor receptor binding;growth factor activity
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Download Datasheet:
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