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Recombinant Human PTPRJ(1024-1306), GST-tagged

Cat.No. : PTPRJ-507H
Product Overview : Recombinant human PTPRJ protein (a.a.1024-1306) with N-terminal GST tag was expressed in anE.coliexpression system, MW= 58.9 kDa.
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Cat. No. : PTPRJ-507H
Description : Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP.
Source : E.coli.
Formulation : 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Purity : > 95% by SDS-PAGE.
Specific Activity : 114 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, and 100 mM NaCl. Enzyme reaction condition: 50 mM HEPES, pH 7.4, 2 Mm EDTA, 3mM DTT, 100 mM NaCl, 20 mM pNPP, and 0.5 ng/µl enzyme, for 5 min at 30°C.
Application : Useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates.
Storage : >6 months at –20°C.
Pathways : Adherens junction
Gene Name : PTPRJ protein tyrosine phosphatase, receptor type, J [ Homo sapiens ]
Synonyms : protein tyrosine phosphatase, receptor type, J; DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA; PTPRJ; DEP-1; EC 3.1.3.48; Density-enhanced phosphatase 1;R-PTP-eta; R-PTP-J; HPTP eta;CD148 antigen density-enhanced phosphatase 1; protein-tyrosine phosphatase eta; human density enhanced phosphatase-1 protein-tyrosine phosphatase receptor type J; receptor-type tyrosine-protein phosphatase eta susceptibility to colon cancer 1, mouse, homolog of; protein tyrosine phosphatase, receptor type, J polypeptide
Gene ID : 5795
mRNA Refseq : NM_001098503
Protein Refseq : NP_001091973
MIM : 600925
UniProt ID : Q12913
Chromosome Location : 11p11.2
Function : hydrolase activity; protein binding; transmembrane receptor protein tyrosine phosphatase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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