Recombinant Human Matrix Metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

• Cat.No.: MMP2-1716H
• Product Overview: Recombinant humanMPP2 expressed by CHOcellsis a 72 kDa Proenzymeprotein.

Specification

• Cat. No.: MMP2-1716H
• Description: 72 kDa type IV collagenase alsoknown as matrix metalloproteinase-2 (MMP2) and gelatinase A is an enzyme thatin humans is encoded by the MMP2 gene. Proteins of the matrixmetalloproteinase (MMP) family are involved in the breakdown of extracellularmatrix in normal physiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in disease processes, such asarthritis and metastasis.
• Concentration: Batch dependent - please inquireshould you have specific requirements.
• Source: Human
• Host: CHO cells
• Form: 150mM NaCl, 20mMTris-HCl, 5mM CaCl2, with 0.05% BRIJ -35 Detergent, pH 7.4.
• Purity: > 90% pure by SDS PAGE
• Molecular Mass: 72 kDa
• Applications: Numerous applications are possiblewith this product and should be tested by the end user under their ownlaboratory conditions.
• Storage: Aliquot and storeat -70 deg C or lower. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: MMP2

Gene Information

• Gene Name: MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDagelatinase, 72kDa type IV collagenase) [ Homo sapiens ]
• Synonyms: MMP2; matrixmetallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase); CLG4; MONA; CLG4A; TBE-1; MMP-II; 72 kDa type IV collagenase; MMP-2; gelatinase A;72 kDa gelatinase; OTTHUMP00000164261; collagenase type IV-A; neutrophilgelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II
• Gene ID: 4313
• mRNA Refseq: NM_001127891
• Protein Refseq: NP_001121363
• MIM: 120360
• UniProt ID: P08253
• Chromosome Location: 16q13-q21
• Pathway: ATF-2 transcription factornetwork; Angiopoietin receptor Tie2-mediated signaling; Bladder cancer;Diabetes pathways; Direct p53 effectors; FOXM1 transcription factor network;GnRH signaling pathway; IL-3 Signaling Pathway; LPA receptor mediated events;Leukocyte transendothelial migration; Matrix Metalloproteinases;Osteopontin-mediated events; Pathways in cancer; Plasma membrane estrogenreceptor signaling; Regulation of Insulin-like Growth Factor (IGF) Activityby Insulin-like Growth Factor Binding Proteins (IGFBPs); Regulation ofWnt-mediated beta catenin signaling and target gene transcription;Syndecan-2-mediated signaling events; Validated transcriptional targets ofAP1 family members Fra1 and Fra2; amb2 Integrin signaling
• Function: metalion binding; metalloendopeptidase activity; peptidase activity; zinc ionbinding