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Native Human Insulin-like Growth Factor Binding Protein 1

Cat.No. : IGFBP1-612H
Product Overview : Native human IGFBP1is a 218 amino acid protein that is a member of a family of six circulatingproteins which bind IGF-I and IGF-II with high affinity and modulate theirmetabolic and mitogenic effects. IGFBP1 appears to inhibit smooth musclemigration in response to IGF-I or IGF-II and to stimulate wound healing inresponse to IGF-II.
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Cat. No. : IGFBP1-612H
Description : This gene is amember of the Insulin-like growth factor-binding protein (IGFBP) family andencodes a protein with an IGFBP domain and a type-I thyroglobulin domain. Theprotein binds both insulin-like growth factors (IGFs) I and II and circulatesin the plasma. Binding of this protein prolongs the half-life of the IGFs andalters their interaction with cell surface receptors. Alternatetranscriptional splice variants, encoding different isoforms, have beencharacterized.
Source : Purified from humanamniotic fluid of individuals that have been shown by certified tests to benegative for hepatitis.
Species : Human
Purity : >95% (by FPLC andSDS-PAGE) Consists of 3-4 phosphorylated forms.
Molecular Weight : 25.3 kDa
State/Appearance : Lyophilized whitepowder dried from 10mM HCI and stored under dry nitrogen at a slight vacuum(-25 kPa).
Biological Activity : Inhibition of IGF-Istimulated proliferation of NUC-1 cells: IC50 ~ 100 ng/ml. Inhibition ofserum-induced stimulation of DNA synthesis in chick embryo fibroblast primarycultures: IC50 (1% serum) ~ 300ng/ml.
Reconstitution : Handling Of IGFBinding Proteins 1-6. Avoid freeze-thaw cycles.
Storage : At least 2 years at2-4°C (lyophilized). In lyophilized form, the IGFBP is stable for at least 2years at 2-4°C, or 6 months at room temperature.
OfficialSymbol : IGFBP1
Pathways : Diabetes pathways;FOXA2 and FOXA3 transcription factor networks; HIF-1-alpha transcriptionfactor network; Myometrial Relaxation and Contraction Pathways; PERKregulated gene expression; Regulation of Insulin-like Growth Factor (IGF)Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs); UnfoldedProtein Response
Gene Name : IGFBP1 insulin-like growthfactor binding protein 1 [ Homo sapiens ]
Synonyms : IGFBP1; insulin-likegrowth factor binding protein 1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1; insulin-likegrowth factor-binding protein 1; IBP-1; IGFBP-1; OTTHUMP00000159561;OTTHUMP00000207990; OTTHUMP00000214348; binding protein-25; bindingprotein-26; binding protein-28; placental protein 12; IGF-binding protein 1;amniotic fluid binding protein; growth hormone independent-binding protein;alpha-pregnancy-associated endometrial globulin; Insulin-like growth factor-binding protein 1;Placental protein 12
Gene ID : 3484
mRNA Refseq : NM_000596
Protein Refseq : NP_000587
MIM : 146730
UniProt ID : P08833
Chromosome Location : 7p13-p12
Function : insulin-like growthfactor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does IGFBP1 contribute to the development and progression of cancers, especially hormone-dependent cancers? 05/02/2022

IGFBP1 influences the progression of certain cancers, particularly those sensitive to hormonal regulation.

How do changes in IGFBP1 expression affect aging and age-related diseases? 12/17/2021

Changes in IGFBP1 expression contribute to the aging process and the development of age-related diseases.

What is the impact of IGFBP1 on fetal growth and development during pregnancy? 12/19/2020

IGFBP1 is important for fetal growth and development, regulating growth factor activity during pregnancy.

How does IGFBP1 influence muscle growth and regeneration, particularly in muscle-wasting conditions? 01/10/2020

IGFBP1 affects muscle growth and regeneration, playing a role in conditions involving muscle wasting.

What are the effects of IGFBP1 on cardiovascular health and diseases such as atherosclerosis? 08/09/2019

IGFBP1 impacts cardiovascular health, influencing factors like blood vessel growth and atherosclerosis development.

What role does IGFBP1 play in metabolic processes, particularly in glucose homeostasis and insulin sensitivity? 01/20/2018

IGFBP1 plays a crucial role in glucose metabolism and insulin sensitivity, impacting overall metabolic health.

How does IGFBP1 regulate the activity of insulin-like growth factors (IGFs) in different tissues? 01/15/2018

IGFBP1 modulates the availability and activity of IGFs, affecting growth and metabolic functions in various tissues.

Customer Reviews (3)

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Reviews
06/13/2022

    Precise antibody validation, enhances immunoprecipitation studies.

    03/12/2019

      Efficient protein purification, delivers high yield and purity.

      06/25/2018

        Dependable expertise in protein engineering, unmatched quality.

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