Active Recombinant Human Tumor Protein P53
Cat.No. : | TP53-1076H |
- Specification
- Gene Information
- Related Products
Cat. No. : | TP53-1076H |
Description : | p53 wild type is His-tagged at the N-terminus. The protein was identified as a tumor suppressor by showing to block the transformation and to inhibit tumor cell growth. In addition, p53 is a transcription factor capable of regulating the expression of a subset of downstream genes. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenes |
Source : | Sf9 insect cells. |
Form : | Liquid. Supplied in 20mM Tris-HCl pH8.0, 20% glycerol, 100mM KCl, 0.2mM EDTA and 1mM DTT. |
Activity : | 1ng is sufficient for a gel mobility shift assay in a 20μl reaction, 50ng are sufficient for reconstituted transcription assay and 100ng are sufficient for a protein-protein interaction assay. |
Application : | Recombinant p53 can be used for: (1) Mobility shift assay or for DNase I footprinting in the presence of double stranded DNA contain a consensus p53- binding sequence [5'-PuPuPuC (A/T) (T/A) GPyPyPy-3']. (2) In vitro transcription assa. (3) Rotein-protein interaction assay. (4) Cell growth assay. |
Purity : | >95% by SDS-PAGE. |
Usage : | For in vitro use only. |
Storage : | Quality guaranteed for 12 months. Store at -80℃. Avoid freeze / thaw cycles. |
Gene Name : | TP53 tumor protein p53 [ Homo sapiens ] |
Synonyms : | TP53; tumor protein p53; p53; LFS1; TRP53; FLJ92943; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; p53 transformation suppressor; p53 tumor suppressor; transformation-related protein 53 |
Gene ID : | 7157 |
mRNA Refseq : | NM_000546 |
Protein Refseq : | NP_000537 |
MIM : | 191170 |
UniProt ID : | P04637 |
Chromosome Location : | 17p13.1 |
Pathway : | Amyotrophic lateral sclerosis (ALS); Apoptosis; Basal cell carcinoma; Bladder cancer; Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; Glioma; Huntington"s disease; MAPK signaling pathway; Melanoma; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Small cell lung cancer; Thyroid cancer; Wnt signaling pathway; p53 signaling pathway; Cell Cycle Checkpoints |
Function : | ATP binding; DNA strand annealing activity; chaperone binding; chromatin binding; copper ion binding; enzyme binding; metal ion binding; promoter binding; protein N-terminus binding; protein heterodimerization activity; transcription factor activity; transcription factor binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
TP53-2547H | Recombinant Human TP53 protein(301-390 aa), C-His-tagged | +Inquiry |
TP53-2772H | Recombinant Human TP53 Protein, His-tagged | +Inquiry |
TP53-4724R | Recombinant Rhesus Macaque TP53 Protein, His (Fc)-Avi-tagged | +Inquiry |
TP53-787C | Recombinant Cynomolgus Monkey TP53 Protein, His (Fc)-Avi-tagged | +Inquiry |
TP53-5887R | Recombinant Rat TP53 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TP53-860HCL | Recombinant Human TP53 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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