Active Native Human Alkaline Phosphatase
Cat.No. : | ALPL-5324H |
Product Overview : | Native human ALPL was purified from Human Liver. |
- Specification
- Gene Information
- Related Products
Description : | Alkaline Phosphatase (ALP) is a hydrolase enzyme responsible for removing phosphate groups in the 5- and 3- positions from many types of molecules, including nucleotides, proteins, and alkaloids. In humans, alkaline phosphatase is present in all tissues throughout the entire body, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta. The optimal pH for the enzyme activity is pH=10 in standard conditions. |
Source : | Human Liver |
Species : | Human |
Form : | Ammonium Sulfate Suspension |
Bio-activity : | >25 U/mL |
Unit Definition : | One unit will convert one micromole of p-nitrophenyl phosphate to p-nitrophenol and phosphate per minute at 37C in the presence of AMP (2-amino-2-methyl-1-propanol) at pH 10.35 |
Storage : | 2-8 °C |
Concentration : | Typically >5 mg protein/mL |
Gene Name : | ALPL alkaline phosphatase, liver/bone/kidney [ Homo sapiens ] |
Official Symbol : | ALPL |
Synonyms : | ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase live |
Gene ID : | 249 |
mRNA Refseq : | NM_000478 |
Protein Refseq : | NP_000469 |
MIM : | 171760 |
UniProt ID : | P05186 |
Chromosome Location : | 1p36.12 |
Pathway : | Endochondral Ossification, organism-specific biosystem; Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem; |
Function : | alkaline phosphatase activity; hydrolase activity; metal ion binding; |
Products Types
◆ Recombinant Protein | ||
ALPL-2458H | Recombinant Human ALPL Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPL-138R | Recombinant Rhesus Macaque ALPL Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPL-327H | Active Recombinant Human ALPL Protein, His-tagged | +Inquiry |
Alpl-564M | Recombinant Mouse Alpl Protein, MYC/DDK-tagged | +Inquiry |
ALPL-297R | Recombinant Rat ALPL Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
ALPL-66C | Active Native Calf Alkaline Phosphatase | +Inquiry |
ALPL-8004H | Native Human Liver Alkaline Phosphatase | +Inquiry |
ALPL-25H | Active Native Human ALPL Protein | +Inquiry |
◆ Lysates | ||
ALPL-3092HCL | Recombinant Human ALPL cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPL exhibits tissue-specific expression, with high levels in mineralizing tissues such as bones and teeth, but lower levels in other organs.
ALPL activity and expression undergo dynamic changes during development and aging, reflecting the physiological demands for mineralization.
ALPL activity can be modulated by factors such as pyrophosphate, calcium, and inhibitors like levamisole, which impact mineralization outcomes.
ALPL plays a critical role in mineralization processes by generating inorganic phosphate, an essential component of hydroxyapatite crystals in bones and teeth.
ALPL can serve as a diagnostic marker for hypophosphatasia and related mineralization disorders, and therapeutic strategies targeting ALPL are being explored.
ALPL deficiency or dysregulation is associated with hypophosphatasia, a genetic disorder characterized by impaired mineralization and skeletal abnormalities.
Genetic variations or mutations in the ALPL gene can lead to altered enzyme activity, affecting mineralization and contributing to disease phenotypes.
Manipulating ALPL activity and function holds promise for promoting bone regeneration and dental tissue engineering, enhancing mineralization processes and tissue formation.
ALPL regulates molecular interactions and signaling pathways, including Wnt/尾-catenin, BMP, and FGF signaling, to orchestrate mineralization processes.
ALPL gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in skeletal development and mineralization.
Customer Reviews (3)
Write a reviewEfficient target protein purification.
Reliable antibody for Western blotting.
Robust enzyme activity measurement.
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