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Active Native Human Alkaline Phosphatase

Cat.No. : ALPL-5324H
Product Overview : Native human ALPL was purified from Human Liver.
  • Specification
  • Gene Information
  • Related Products
Description : Alkaline Phosphatase (ALP) is a hydrolase enzyme responsible for removing phosphate groups in the 5- and 3- positions from many types of molecules, including nucleotides, proteins, and alkaloids. In humans, alkaline phosphatase is present in all tissues throughout the entire body, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta. The optimal pH for the enzyme activity is pH=10 in standard conditions.
Source : Human Liver
Species : Human
Form : Ammonium Sulfate Suspension
Bio-activity : >25 U/mL
Unit Definition : One unit will convert one micromole of p-nitrophenyl phosphate to p-nitrophenol and phosphate per minute at 37C in the presence of AMP (2-amino-2-methyl-1-propanol) at pH 10.35
Storage : 2-8 °C
Concentration : Typically >5 mg protein/mL
Gene Name : ALPL alkaline phosphatase, liver/bone/kidney [ Homo sapiens ]
Official Symbol : ALPL
Synonyms : ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase live
Gene ID : 249
mRNA Refseq : NM_000478
Protein Refseq : NP_000469
MIM : 171760
UniProt ID : P05186
Chromosome Location : 1p36.12
Pathway : Endochondral Ossification, organism-specific biosystem; Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem;
Function : alkaline phosphatase activity; hydrolase activity; metal ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is the tissue-specific expression pattern of ALPL in different organs and cell types? 12/11/2022

ALPL exhibits tissue-specific expression, with high levels in mineralizing tissues such as bones and teeth, but lower levels in other organs.

How does ALPL activity and expression change during development and aging? 09/09/2022

ALPL activity and expression undergo dynamic changes during development and aging, reflecting the physiological demands for mineralization.

Can ALPL activity be modulated by specific factors or inhibitors, and how does this affect mineralization? 06/23/2021

ALPL activity can be modulated by factors such as pyrophosphate, calcium, and inhibitors like levamisole, which impact mineralization outcomes.

How does ALPL contribute to mineralization processes, such as bone formation and tooth development? 10/26/2019

ALPL plays a critical role in mineralization processes by generating inorganic phosphate, an essential component of hydroxyapatite crystals in bones and teeth.

Can ALPL serve as a diagnostic marker or therapeutic target for mineralization-related diseases? 02/27/2019

ALPL can serve as a diagnostic marker for hypophosphatasia and related mineralization disorders, and therapeutic strategies targeting ALPL are being explored.

How does ALPL deficiency or dysregulation contribute to the pathogenesis of skeletal and dental disorders, such as hypophosphatasia? 08/21/2018

ALPL deficiency or dysregulation is associated with hypophosphatasia, a genetic disorder characterized by impaired mineralization and skeletal abnormalities.

What are the effects of genetic variations or mutations in the ALPL gene on enzyme activity and mineralization phenotypes? 12/19/2017

Genetic variations or mutations in the ALPL gene can lead to altered enzyme activity, affecting mineralization and contributing to disease phenotypes.

How can ALPL activity and function be manipulated to enhance bone regeneration and dental tissue engineering? 08/22/2017

Manipulating ALPL activity and function holds promise for promoting bone regeneration and dental tissue engineering, enhancing mineralization processes and tissue formation.

What are the downstream signaling pathways and molecular interactions regulated by ALPL in mineralization processes? 05/18/2017

ALPL regulates molecular interactions and signaling pathways, including Wnt/尾-catenin, BMP, and FGF signaling, to orchestrate mineralization processes.

What are the regulatory mechanisms controlling ALPL gene expression and enzymatic activity? 01/09/2017

ALPL gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in skeletal development and mineralization.

Customer Reviews (3)

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Reviews
04/22/2022

    Efficient target protein purification.

    04/05/2018

      Reliable antibody for Western blotting.

      12/20/2017

        Robust enzyme activity measurement.

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