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Recombinant Human Colony Stimulating Factor 1 (macrophage)

Cat.No. : CSF1-357H
Product Overview : Recombinanthuman CSF1is a single, non-glycosylated polypeptide chain containing 150 amino acids,MW 42.0 kDa.CSF1is expressed in SF9 cells, MW 42.0 kDa.
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Cat. No. : CSF1-357H
Description : Macrophagecolony-stimulating factor, or CSF1, is a secreted cytokine which influenceshematopoietic stem cells to differentiate into macrophages or other relatedcell types. Eukaryotic cells also produce CSF1 in order to combat intercellularviral infection. (See colony-stimulating factor.) CSF1 binds to the Colonystimulating factor 1 receptor. It may also be involved in development of theplacenta.
Source : Human
Host : SF9 cells
Form : Lyophilizedfrom a 0.2 μm filtered solution in 20 mM PB + 1% HSA + 3% Mannitol.
Purity : >95% by SDS-PAGEand HPLC.
Sequence : EEVSEYCSHMIGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQLQELSLRLKSC FTKDYEEHDKACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQ
Molecular Weight : 42.0 kDa
Biological Activity : Fullybiologically active when compared to standard. Determined by thedose-dependant stimulation of the proliferation of murine M-NSF-60 cells. TheED is <3.0 ng/Ml.
Endotoxin Level : <1EU/µg of MCSF.
Reconstitution : Centrifugevial prior to opening. Add sterile distilled water or aqueous buffer containing0.1% BSA to a concentration of 0.1-1.0 mg/mL. Please note that the additionof any carrier protein into this product may produce unwanted endotoxin. Thisdepends upon the particular application employed. Further dilutions should bemade in appropriate buffered solutions.
Storage : Stableat 2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for upto 1 week at 2-8°C. For longer term, store in working aliquots below -20°C. Avoidrepeated freeze/thaw cycles.
OfficialSymbol : CSF1
Gene Name : CSF1colony stimulating factor 1 (macrophage) [ Homo sapiens ]
Synonyms : CSF1; colonystimulating factor 1 (macrophage); MCSF; M-CSF; CSF-1; MGC31930; macrophagecolony stimulating factor; macrophage colony-stimulating factor 1;Lanimostim; lanimostim; OTTHUMP00000013362; OTTHUMP00000013363;OTTHUMP00000013364; OTTHUMP0-0000013365; EC 2.7.10.1
Gene ID : 1435
mRNA Refseq : NM_000757
Protein Refseq : NP_000748
MIM : 120420
UniProt ID : P09603
Chromosome Location : 1p21-p13
Pathway : Cytokine-cytokinereceptor interaction; Cytokines and Inflammatory Response; Hematopoietic celllineage; Integrins in angiogenesis; Osteoclast differentiation; Rheumatoidarthritis; Signaling events mediated by PTP1B; Signaling events mediated byTCPTP
Function : cytokineactivity; growth factor activity; macrophage colony-stimulating factorreceptor binding; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CSF1 affect cancer progression? 09/20/2022

CSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.

What are the potential side effects of CSF1 therapy? 07/11/2022

Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.

Can CSF1 therapy be combined with other treatments? 08/26/2020

Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.

What are the challenges in developing CSF1-based therapies? 09/26/2019

Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.

In what ways is CSF1 being researched for neurological disorders? 10/01/2018

Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.

Customer Reviews (3)

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Reviews
10/30/2017

    The CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.

    03/10/2017

      With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.

      06/09/2016

        Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.

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