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Recombinant Mouse Colony Stimulating Factor 2 (granulocyte-macrophage)

Cat.No. : Csf2-370M
Product Overview : Recombinantmouse Csf2 is a disulfide-linked monomer protein, consisting of 125 aminoacids and migrates as an approximately 14 kDa protein under reducingconditions, and was lyophilized from 0.2 μm filtered PBSsolution, pH 7.0.
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Cat. No. : Csf2-370M
Description : Csf2 is amonomeric protein of 127 amino acids with two glycosylation sites. Theprotein is synthesized as a precursor of 144 amino acids, which included ahydrophobic secretory signal sequence at the aminoterminal end. The sugarmoiety is not required for the full spectrum of biological activities. Non-glycosylated and glycosylated Csf2 show the same activities in vitro. Fullyglycosylated Csf2 is biologically more active in vivo than the non-glycosylated protein. This protein is secreted together with other factors byT-cells and macrophages following cell activation by antigens or mitogens.
Source : Mouse
Host : E. coli
Purity : >95%, asdetermined by SDS-PAGE and HPLC.
Sequence : MWLQNLLFLGIVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL NEEVEVVSNE FSFKKLTCVQ TRLKIFEQGLRGNFTKLKGA LNMTASYYQT YCPPTPETDC ETQVTTYADF IDSLKTFLTD IPFECKKPGQ K
Molecular Weight : Native MouseGranulocyte Macrophage-Colony Stimulating Factor is generated by the proteolyticremoval of the signal peptide and propeptide, this molecule has a calculated massof 14 kDa.
Biological Activity : The ED50 asdetermined by the dose-dependent stimulation of the proliferation of murineFDC-P1 cells is ≤ 0.1ng/ml, corresponding to a specific activity of ≥ 3 x 106units/mg.
Endotoxin : Endotoxincontent was assayed using a LAL gel clot method. Endotoxin level was foundto be less than 0.1 ng/µg(1EU/µg).
Reconstitution : A quick spin of thevial followed by reconstitution in distilled water to a concentration notless than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage : Thelyophilized protein is stable for at least 2 years from date of receipt at-20°C. Upon reconstitution, this cytokine can be stored in working aliquots at2°C - 8°C for one month, or at -20°C for six months, with a carrier proteinwithout detectable loss of activity. Avoid repeated freeze/thaw cycles.
OfficialSymbol : Csf2
Pathways : Amoebiasis;Cytokine Signaling in Immune system; Cytokine-cytokine receptor interaction; Fcepsilon RI signaling pathway; HTLV-I infection; Hematopoietic cell lineage; ImmuneSystem; Interleukin receptor SHC signaling; Interleukin-2 signaling; Jak-STATsignaling pathway; Natural killer cell mediated cytotoxicity; Rheumatoidarthritis; Salmonella infection; Signaling by Interleukins; T cell receptorsignaling pathway
Gene Name : Csf2 colony stimulating factor 2 (granulocyte-macrophage)[ Mus musculus ]
Synonyms : Csf2; colony stimulating factor 2 (granulocyte-macrophage);Csfgm;Gm-CSf; MGI-IGM; MGC151255; MGC151257; granulocyte-macrophagecolony-stimulating factor; CSF; put. GM-CSF; OTTMUSP00000005830;colony-stimulating factor; granulocyte-macrophage colony stimulating factor 2
Gene ID : 12981
mRNA Refseq : NM_009969
Protein Refseq : NP_034099
UniProt ID : P01587
Function : cytokineactivity; granulocyte macrophage colony-stimulating factor receptor binding; growthfactor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How conserved is the sequence of CSF2 among different species? 05/15/2021

The sequence of CSF2 is moderately conserved across different species.

What is the typical length of CSF2? 01/30/2021

The length of CSF2 protein varies but is typically around 144 amino acids.

What is the main biological function of CSF2? 05/01/2019

The primary function of CSF2 is to regulate the production and differentiation of white blood cells.

In what tissues or cells is CSF2 commonly expressed? 02/03/2019

CSF2 is often expressed in immune cells, specifically in macrophages, T cells, and endothelial cells.

What does CSF2 stand for? 07/10/2018

CSF2 stands for Colony Stimulating Factor 2.

Is CSF2 associated with any specific diseases or conditions? 03/17/2018

CSF2 dysregulation has been linked to autoimmune diseases and inflammatory disorders.

Which cellular functions are associated with CSF2? 02/20/2017

CSF2 is involved in the stimulation of stem cells to produce granulocytes and monocytes.

Customer Reviews (3)

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Reviews
01/15/2022

    The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.

    07/27/2021

      The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.

      05/19/2019

        Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.

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