Recombinant Rat Choline O-Acetyltransferase
Cat.No. : | Chat-1836R |
Product Overview : | Recombinant Rat Chat wasexpressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Chat-1836R |
Description : | Chat is arecombinant protein corresponding to rat Choline Acetyltransferase (Chat), anenzyme that catalyzes the reversible synthesis of acetylcholine (ACh) fromacetyl CoA and choline at cholinergic synapses. |
Form : | Purified recombinantChat - liquid. |
Application : | Immunohistology -Frozen |
Preparation : | Purified recombinant rat choline acetyltransferase expressed in Escherichia coli. |
Concentration : | Total protein concentration 0.25 mg/ml. |
Storage : | Store at -20oC only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. |
Gene Name : | Chat choline O-acetyltransferase[ Rattus norvegicus ] |
Official Symbol : | Chat |
Synonyms : | Chat; choline O-acetyltransferase; choline O-acetyltransferase; CHOACTase;choline acetylase; choline acetyltransferase |
Gene ID : | 290567 |
mRNA Refseq : | NM_001170593 |
Protein Refseq : | NP_001164064 |
Chromosome Location : | 16p16 |
Pathway : | AcetylcholineNeurotransmitter Release Cycle; Biogenic Amine Synthesis; Cholinergicsynapse; Glycerophospholipid metabolism; Neurotransmitter Release Cycle;Synaptic Transmission; Transmission across Chemical Synapses |
Function : | choline O-acetyltransferaseactivity; choline binding; transferase activity, transferring acyl groups |
Products Types
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
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Q&As (6)
Ask a questionThe activity of the CHAT protein can be modulated by drugs or other small molecule compounds to treat neurological disorders associated with CHAT protein abnormalities. For example, some drugs can promote the expression and activity of the CHAT protein, thereby increasing acetylcholine synthesis.
Expression level of CHAT protein is regulated by a variety of factors, including gene expression, post-transcriptional modifications, nutritional status, etc. Some drugs or other small molecule compounds can also affect their expression levels by regulating gene expression or post-transcriptional modifications.
Some studies have shown that mutations or abnormal expression of the CHAT protein may be related to neurological diseases, psychiatric diseases, etc. However, further research is needed to confirm the association.
CHAT protein has some association with other neurotransmitters or signaling molecules. For example, it can interact with cholinergic neurons to co-regulate acetylcholine synthesis and release. In addition, it can interact with other neurotransmitters or signaling molecules such as dopamine, glutamate, etc.
The occurrence, progression and prognosis of neurological diseases can be assessed by detecting characteristics such as the expression level, activity and interaction of CHAT protein with other proteins. These features can also be used to develop new biomarkers and drug targets.
Some studies have shown that abnormal expression of CHAT protein may be related to the occurrence and progression of some neurological diseases, such as Alzheimer's disease and Parkinson's disease. In addition, the CHAT protein may also be a drug target for the treatment of these diseases.
Customer Reviews (3)
Write a reviewThe resolution of CHAT in Western blot is high and can distinguish between similar protein molecular weights.
This repeatability of CHAT is very good, which can greatly reduce the experimental error and allow me to evaluate the experimental results more accurately.
Stability of CHAT is so good that a variety of experimental manipulations can be performed without concern for changes and effects on its properties.
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