Recombinant Human Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 1, His-tagged

• Cat.No.: GNB2L1-1375H
• Product Overview: Recombinant humanGNB2L1 protein, fused to His-tag at N-terminus, wasexpressed in E.coli and purified by using conventional chromatography.

Specification

• Cat. No.: GNB2L1-1375H
• Description: GNB2L1 wasoriginally identified as an anchoring protein for protein kinase C beta(PKCbeta), which it stabilises in the active state and anchors to membranesor functional sites. However, evidence has accumulated to support a centralrole of GNB2L1 in critical biological responses.
• Form: Liquid. In 20 mMTris-HCl buffer (pH 8.0) containing 5 mM DTT, 50% glycerol, 0.2M NaCl.
• Molecular Weight: 37.2 kDa (337 aa)confirmed by MALDI-TOF.
• Purity: > 90%by SDS-PAGE
• Concentration: 0.25 mg/ml(determined by Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDETNYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQIVSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA NCKLKTNHIGHTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC FSPNRYWLCA ATGPSIKIWDLEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA GYTDNLVRVW QVTIGTR
• Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: CXCR4-mediatedsignaling events; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha;IGF1 pathway; IL-2 Signaling Pathway; IL-3 Signaling Pathway; Measles;Regulation of Androgen receptor activity; Syndecan-2-mediated signalingevents; TNF receptor signaling pathway; TNF-alpha/NF-kB Signaling Pathway

Gene Information

• Gene Name: GNB2L1 guanine nucleotidebinding protein (G protein), beta polypeptide 2-like 1 [ Homo sapiens]
• Official Symbol: GNB2L1
• Synonyms: GNB2L1;guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; H12.3; HLC-7; PIG21; RACK1; Gnb2-rs1;guanine nucleotide-binding protein subunit beta-2-like 1; OTTHUMP00000223704;OTTHUMP00000223870; OTTHUMP00000223891; OTTHUMP00000223893;OTTHUMP00000223900; OTTHUMP00000223902; OTTHUMP00000223930; OTTHUMP00000223931;lung cancer oncogene 7; proliferation-inducing gene 21; Receptor forActivated C Kinase 1; human lung cancer oncogene 7 protein; receptor ofactivated protein kinase C 1; cell proliferation-inducing gene 21 protein;guanine nucleotide-binding protein subunit beta-like protein 12.3; proteinhomologous to chicken B complex protein, guanine nucleotide binding
• Gene ID: 10399
• mRNA Refseq: NM_006098
• Protein Refseq: NP_006089
• MIM: 176981
• UniProt ID: P63244
• Chromosome Location: 5q35.3
• Function: SH2domain binding; ion channel inhibitor activity; protein binding; proteinkinase C binding; protein phosphatase binding; protein tyrosine kinaseinhibitor activity; receptor binding; receptor tyrosine kinase binding