Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, Cys-tagged

• Cat.No.: SERPINE1-5493H
• Product Overview: RecombinantHuman SERPINE1 NBD P1" Mutant was created by mutagenesis of the P1" serineresidue (Ser347) at the P1-P1" scissile bond to cysteine. This then providesa free thiol group for NBD labeling, a fluorescent probe highly sensitive tochanges in solvation and hydrophobic environment. The fluorescence emission ofthe product is quenched upon cleavage of the reactive center loop by a targetproteinase.

Specification

• Cat. No.: SERPINE1-5493H
• Description: SERPINE1is a protein that in humans is encoded by the SERPINE1 gene. SERPINE1 is aserine protease inhibitor (serpin) that functions as the principal inhibitorof tissue plasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein.
• Source: E. coli
• Species: Human
• Form: Frozenliquid in 0.05 M sodium phosphate + 0.1 M NaCl + 1 mM EDTA, pH 6.6.
• Concentration: 2.5 mg/ml
• Molecular Weight: 43.0 kDa
• Storage: Store inworking aliquots at -80°C, protected from light. Avoid repeated freeze-thawcycles.
• OfficialSymbol: SERPINE1

Gene Information

• Gene Name: SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1 [ Homo sapiens ]
• Synonyms: SERPINE1; serpin peptidase inhibitor, cladeE (nexin, plasminogen activator inhibitor type 1), member 1; Plasminogen activator inhibitor 1; Endothelialplasminogen activator inhibitor; PAIE; Clade E; PLANH1; SERPINE 1; PAI;PAI-1; PAI1; plasminogen activator inhibitor-1; plasminogen activator inhibitor,type I; serine (or cysteine) proteinase inhibitor, clade E (nexin,plasminogen activator inhibitor type 1), member 1; Endothelial plasminogenactivator inhibitor
• Gene ID: 5054
• mRNA Refseq: NM_000602
• Protein Refseq: NP_000593
• MIM: 173360
• UniProt ID: P05121
• Chromosome Location: 7q21.3-q22
• Pathway: Adipogenesis; BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade; Chagas disease(American trypanosomiasis); Circadian Clock; Complement and CoagulationCascades; Direct p53 effectors; Dissolution of Fibrin Clot; E2F transcriptionfactor network; HIF-1-alpha transcription factor network; HIF-2-alphatranscription factor network; Hemostasis; Platelet activation; Plateletdegranulation; Regulation of nuclear SMAD2/3 signaling
• Function: peptidase inhibitor activity;protease binding; protein binding; serine-type endopeptidase inhibitoractivity; contributes to receptor binding