Recombinant Human Ret Proto-Oncogene, GST-tagged
Cat.No. : | RET-5475H |
Product Overview : | Recombinant humanRET catalytic domain (amino acids 658-1114) with GST tag, activated in vitrovia auto-phosphorylation. |
- Specification
- Gene Information
- Related Products
Cat. No. : | RET-5475H |
Description : | The RETproto-oncogene encodes a receptor tyrosine kinase for members of the glialcell line-derived neurotrophic factor family of extracellular signallingmolecules. RET loss of function mutations are associated with the developmentof Hirschsprung" s disease, while gain of function mutations are associatedwith the development of various types of human cancer. |
Source : | Insect cells |
Species : | Human |
Form : | Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol. |
Purity : | ≥ 90% as determinedby SDS-PAGE analysis |
MolecularWeight : | 79.0 kDa |
Specific Activity : | 2382 nmole ofphosphate transferred to Abl1 peptide substrate (EAIYAAPFAKKK) per minute permg of total protein at 30°C. Activity determined at a final proteinconcentration of 1.67 μg/ml. |
Concentration : | 0.31 mg/ml |
Storage : | Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | RET |
Pathways : | Endocytosis;Pathways in cancer; SIDS Susceptibility Pathways; Signaling events regulatedby Ret tyrosine kinase; Thyroid cancer |
Gene Name : | RET ret proto-oncogene [ Homosapiens ] |
Synonyms : | RET; retproto-oncogene; PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16;RET-ELE1; proto-oncogenetyrosine-protein kinase receptor Ret; OTTHUMP00000019479; OTTHUMP00000216967;proto-oncogene c-Ret; receptor tyrosine kinase; RET transforming sequence;cadherin family member 12; hydroxyaryl-protein kinase; cadherin-relatedfamily member 16; ret proto-oncogene (multiple endocrine neoplasia andmedullary thyroid carcinoma 1, Hirschsprung disease); EC 2.7.10.1; Proto-oncogene tyrosine-protein kinasereceptor Ret; Cadherinfamily member 12; Proto-oncogene c-Ret |
Gene ID : | 5979 |
mRNA Refseq : | NM_020630 |
Protein Refseq : | NP_065681 |
MIM : | 164761 |
UniProt ID : | P07949 |
Chromosome Location : | 10q11.2 |
Function : | ATP binding; calciumion binding; nucleotide binding; protein binding; protein tyrosine kinaseactivity; receptor activity; transmembrane receptor protein tyrosine kinaseactivity |
Products Types
◆ Recombinant Protein | ||
Ret-10611M | Recombinant Mouse Ret Protein, His (Fc)-Avi-tagged | +Inquiry |
RET-7010H | Recombinant Human RET protein(Met1-Arg635), His-tagged | +Inquiry |
RET-716H | Recombinant Human RET Protein, His-tagged | +Inquiry |
Ret-2014M | Recombinant Mouse Ret Protein, His-tagged | +Inquiry |
RET-91H | Active Recombinant Human RET Protein, GST-His-tagged | +Inquiry |
◆ Lysates | ||
RET-570HCL | Recombinant Human RET cell lysate | +Inquiry |
RET-1822HCL | Recombinant Human RET cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket