Recombinant Human Vascular Endothelial Growth Factor A

• Cat.No.: VEGFA-5530H
• Product Overview: Recombinant human VEGF121is expressed in human 293 cells as a glycosylated cytokine with an apparentmolecular mass of 37 kDa as dimer and 50 kDa as trimer.

Specification

• Cat. No.: VEGFA-5530H
• Description: This gene is amember of the platelet-derived growth factor (PDGF)/vascular endothelialgrowth factor (VEGF) family and encodes a protein that is often found as adisulfide linked homodimer. This protein is a glycosylated mitogen thatspecifically acts on endothelial cells and has various effects.
• Source: HEK 293 cells
• Species: Human
• Purity: >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
• Molecular Mass: 80 to 85 kDa,monomer, glycosylated.
• Endotoxin Level: Endotoxin Free <1EU/μg
• Biological Activity: 2 to 8 ng/mL ED50
• Specific Activity: The specificactivity was determined by the dose-dependent stimulation of theproliferation of HUVEC cells (Human Umbilical Vein Endothelial Cells).
• OfficialSymbol: VEGFA
• Pathways: Bladder cancer;Cytokine-cytokine receptor interaction; Endochondral Ossification; Focaladhesion; Glypican 1 network; HIF-1-alpha transcription factor network;HIF-2-alpha transcription factor network; Heart Development; Hemostasis;Hypertrophy Model; Id Signaling Pathway; Integrins in angiogenesis;Neurophilin interactions with VEGF and VEGFR; Pancreatic cancer; Pathways incancer

Gene Information

• Gene Name: VEGFA vascular endothelialgrowth factor A [ Homo sapiens ]
• Synonyms: VEGFA;vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascularendothelial growth factor A; OTTHUMP00000016487; OTTHUMP00000016488;OTTHUMP00000165985; OTTHUMP00000165986; OTTHUMP00000165987;OTTHUMP00000224107; OTTHUMP00000224108; OTTHUMP00000224109;OTTHUMP00000224153; OTTHUMP00000224154; OTTHUMP00000224423;OTTHUMP00000224424; OTTHUMP00000224425; OTTHUMP00000224426;OTTHUMP00000224427; OTTHUMP00000224428; OTTHUMP00000224429;OTTHUMP00000224430; vascular permeability factor; Vascular endothelial growth factor A; Vascular permeability factor
• Gene ID: 7422
• mRNA Refseq: NM_001025366
• Protein Refseq: NP_001020537
• MIM: 192240
• UniProt ID: P15692
• Chromosome Location: 6p12
• Function: cell surfacebinding; chemoattractant activity; cytokine activity; extracellular matrixbinding; fibronectin binding; growth factor activity; heparin binding;platelet-derived growth factor receptor binding; protein binding; proteinheterodimerization activity; vascular endothelial growth factor receptor 1binding; vascular endothelial growth factor receptor 2 binding; vascularendothelial growth factor receptor binding