Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1
Cat.No. : | SERPINE1-5511H |
Product Overview : | Recombinant HumanPlasminogen Activator Inhibitor type 1 tPA Complex. Human PAI-1 stable mutantis reacted with an excess of human sc-tPA at physiological pH. SERPINE1 wasexpressed in E. coli, which having a molecule weight of 97.0 kDa. |
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- Gene Information
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Cat. No. : | SERPINE1-5511H |
Description : | SERPINE1 also knownas endothelial plasminogen activator inhibitor or serpin E1 is a protein thatin humans is encoded by the SERPINE1 gene. SERPINE1 is a serine proteaseinhibitor (serpin) that functions as the principal inhibitor of tissueplasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein (SERPINE1). Theother PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by theplacenta and only present in significant amounts during pregnancy. In addition,protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, isthe main inhibitor of the plasminogen activators. |
Source : | E. coli |
Species : | Human |
Molecule Weight : | 97.0 kDa |
Form : | Liquid in 0.1 MTris-HCl + 0.15 M NaCl, pH 7.4. |
Concentration : | 1.0 mg/ml |
Storage : | Storein working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | SERPINE1 |
Pathways : | Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade;Complement and Coagulation Cascades; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-2-alpha transcription factor network;Platelet activation; Platelet degranulation; Regulation of nuclear SMAD2/3signaling; Response to elevated platelet cytosolic Ca2+; Selenium Pathway;Senescence and Autophagy; TGF Beta Signaling Pathway; p53 signaling pathway |
Gene Name : | SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ] |
Synonyms : | SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpinE1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine(or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activatorinhibitor type 1), member 1 |
Gene ID : | 5054 |
mRNA Refseq : | NM_000602 |
Protein Refseq : | NP_000593 |
MIM : | 173360 |
UniProt ID : | P05121 |
Chromosome Location : | 7q21.3-q22 |
Function : | peptidase inhibitoractivity; protease binding; protein binding; contributes to receptor binding;serine-type endopeptidase inhibitor activity |
Products Types
◆ Native Protein | ||
SERPINE1-5514R | Native Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 | +Inquiry |
SERPINE1-29522TH | Native Human SERPINE1 | +Inquiry |
◆ Lysates | ||
SERPINE1-001RCL | Recombinant Rat SERPINE1 cell lysate | +Inquiry |
SERPINE1-2383HCL | Recombinant Human SERPINE1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0782 | SERPINE1 (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionYes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.
Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.
SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.
The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.
In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.
In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.
Customer Reviews (3)
Write a reviewIt has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
When used for experiments, the experimental conditions and results are highly repeatable.
SERPINE1 has good solubility and is easy to operate and purify.
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