Active Recombinant Mouse IL18BP, His tagged
Cat.No. : | IL18BP-767M |
Product Overview : | Recombinant Mouse IL18BP precursor (NP_034661.1) (Met 1-Ala 193), fused with the polyhistide tag at the C-terminus, was produced in Human Cell. |
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Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized from sterile 50 mM Tris, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized IL18BP Protein, Mouse, (His Tag) at 2 μg/mL (100 μL/well) can bind IL-18 Protein, Mouse Biotinylated, the EC50 of Biotinylated Mouse IL-18 is 25-80 μg/mL. |
Molecular Mass : | The recombinant mouse IL18BP comprises 176 amino acids and has a predicted molecular mass of 19.4 kDa. In SDS-PAGE under reducing conditions, rm IL18BP migrates between 35-50 kDa due to different glycosylation. |
Protein Length : | Met 1-Ala 193 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Publication : |
Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome (2020)
Detection of Free Bioactive IL-18 and IL-18BP in Inflammatory Disorders (2023)
Interleukin-18 as a Therapeutic Target in Western-diet Induced Cardiomyopathy (2017)
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Gene Name : | Il18bp interleukin 18 binding protein [ Mus musculus ] |
Official Symbol : | IL18BP |
Synonyms : | IL18BP; interleukin 18 binding protein; interleukin-18-binding protein; interferon gamma inducing factor binding protein; interferon gamma-inducing factor-binding protein; MC54L; Igifbp; IL-18BP; |
Gene ID : | 16068 |
mRNA Refseq : | NM_010531 |
Protein Refseq : | NP_034661 |
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◆ Lysates | ||
IL18BP-2674MCL | Recombinant Mouse IL18BP cell lysate | +Inquiry |
IL18BP-2918HCL | Recombinant Human IL18BP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionGenetic association studies, sequencing analyses, and functional investigations explore how genetic variations in IL18BP might influence disease susceptibility and outcomes.
Knockout mice, transgenic models, and imaging techniques provide insights into IL18BP's impact on IL18-related immune responses in vivo.
Promoter studies, siRNA knockdown, and cytokine stimulation assays investigate IL18BP regulation at the transcriptional and post-transcriptional levels.
Luciferase reporter assays, ELISAs, and functional cell assays probe how IL18BP modulates IL18-induced cytokine production and immune cell activation.
Biophysical techniques, site-directed mutagenesis, and receptor binding assays reveal potential allosteric effects on IL18 signaling.
Surface plasmon resonance, isothermal titration calorimetry, and kinetic binding assays quantify IL18BP-IL18 interactions.
RT-qPCR, immunohistochemistry, and tissue microarray analyses determine the expression patterns of IL18BP in different tissues and diseases.
X-ray crystallography, NMR spectroscopy, and mutagenesis studies elucidate the structural basis of IL18BP-IL18 recognition.
Cross-competition assays, co-stimulation studies, and receptor activation assays unveil potential interplay between IL18BP and other cytokine regulators.
Therapeutic antibody trials, in vitro functional screens, and disease model assessments evaluate IL18BP modulation as a potential anti-inflammatory strategy.
Customer Reviews (3)
Write a reviewConsistent binding affinity.
High purity.
Effective in neutralization assays.
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