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Cat. No.
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CCR5-366H
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Product Overview
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CCR5 peptide is usedfor blocking the activity of Anti-CCR5.
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Description
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CCR5 is a proteinthat in humans is encoded by the CCR5 gene. CCR5 is a member of the betachemokine receptors family of integral membrane proteins. The CCR5 proteinhas also recently been designated CD195.In humans, the CCR5 gene location ison the short (p) arm at position 21 on chromosome 3. Certain populations haveinherited the Delta 32 mutation resulting in the genetic deletion of aportion of the CCR5 gene. Homozygous carriers of this mutation are resistantto M-tropic strains of HIV-1 infection.
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Source
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bovineserum albumin
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Species
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Human
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Form
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Liquid inPBS, pH 7.2 (10 mM NaH2PO4+ 130 mM NaCl) containing 0.1% bovine serum albuminand 0.02% sodium azide. Precaution: Sodium azide is a poisonous and hazardoussubstance which should be handled by trained staff only.
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Applications
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Incubatingthe peptide with equal volume of antibody for 30 min at 37oC usually completelyblocks the activity of Anti-CCR5 in Western blot.
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Storage
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When stored at -20oC, stable for oneyear from date of receipt.
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Gene Information
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GeneName
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CCR5chemokine (C-C motif) receptor 5 [ Homo sapiens ]
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OfficialSymbol
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CCR5
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Synonyms
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CCR5; chemokine(C-C motif) receptor 5; CKR5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22;CC-CKR-5; FLJ78003; OTTHUMP00000164715; OTTHUMP00000209784; C-C chemokinereceptor type 5; CHEMR13; HIV-1 fusion coreceptor; C-C motif chemokine receptortype 5 A159A; chemokine receptor CCR5; chemr13; CD195 antigen
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GeneID
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1234
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mRNA Refseq
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NM_000579
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Protein Refseq
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NP_000570
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MIM
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601373
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UniProt ID
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P51681
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ChromosomeLocation
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3p21
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Pathway
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Binding and entry ofHIV virion; Chemokine receptors bind chemokines; Chemokine signaling pathway;Class A/1 (Rhodopsin-like receptors); Cytokine-cytokine receptor interaction;Early Phase of HIV Life Cycle; Endocytosis; G alpha (i) signalling events; GPCRdownstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like’ GPCRs,Other; HIV Infection; HIV Life Cycle; IL12-mediated signaling events; PeptideGPCRs; Signal Transduction; Signaling by GPCR; Toxoplasmosis
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Function
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C-C chemokine receptor activity; G-proteincoupled receptor activity; actin binding; chemokine receptor activity; coreceptoractivity; phosphatidylinositol phospholipase C activity; protein binding; receptoractivity; signal transducer activity
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Renderingbased on PDB 1ND8.
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Download Datasheet:
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