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Recombinant Human Defensin, Beta 4A

Cat.No. : DEFB4A -5387H
Product Overview : Recombinant HumanDefensin beta 4 is a single, non-glycosylated polypeptide chain containing 50amino acids.
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Cat. No. : DEFB4A -5387H
Description : DEFB4A also known as skin-antimicrobial peptide 1(SAP1) is a peptide that in humans is encoded by the DEFB4 (defensin, beta 4)gene. Human DEFB4A is a cysteine-rich cationic low molecularweight antimicrobial peptide recently discovered in lesional skin.
Source : E. coli
Species : Human
Form : Lyophilized from asterile filtered solution in 20 mM PBS, pH 7.4 + 130 mM NaCl.
Molecular Weight : 6.0 kDa
Purity : > 98% by HPLC andSDS-PAGE.
Endotoxin Level : < 0.1 ng/µg ofDefensin beta 4.
Biological Activity : Determined by itsability to chemoattract human monocytes using a concentration range of 0.1-50ng/mL.
Sequence : EFELDRICGYGTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP
Reconstitution : Centrifuge vialprior to opening. Add sterile distilled water or aqueous buffer to a concentrationof 0.1-1.0 mg/mL. Further dilutions should be made in appropriate bufferedsolutions.
Storage : Stable at 2-8°C, butbest kept desiccated -20°C. Upon reconstitution, stable for up to 1 week at2-8°C. For longer term, store in working aliquots below -20°C. Avoid repeatedfreeze/thaw cycles.
OfficialSymbol : DEFB4A
Gene Name : DEFB4A defensin, beta 4A [ Homosapiens ]
Synonyms : DEFB4A; defensin,beta 4A; BD-2; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102; hBD-2;beta-defensin 4A; Skin-antimicrobial peptide 1; defensin, beta 2; defensin,beta 4; OTTHUMP00000159651; skin-antimicrobial peptide 1; Defensin, beta 2;Skin-antimicrobial peptide 1
Gene ID : 1673
mRNA Refseq : NM_004942
Protein Refseq : NP_004933
MIM : 602215
UniProt ID : O15263
Chromosome Location : 8p23.1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can the structure of DEFB4A be evaluated? 05/25/2023

DEFB4A has a typical β-defensin structure consisting of a cysteine-rich mature peptide region and a positively charged N-terminal region. This structure allows it to bind and destroy the cell membranes of pathogenic microorganisms.

Which biomolecules can be used as molecular markers for DEFB4A? 03/16/2023

Biomolecules that can be used as molecular markers for DEFB4A include its mRNA and protein expression products in tissues and cells, as well as other biomolecules (e.g., receptors, signal transduction molecules, etc.) that interact with it.

What diseases are associated with the aberrant expression of DEFB4A? 07/26/2022

The abnormal expression of DEFB4A is associated with a variety of inflammatory and infectious diseases, such as psoriasis, atopic dermatitis, chronic sinusitis, etc. In addition, the expression of DEFB4A has also been found to be associated with the occurrence and progression of certain tumors.

What are the treatment strategies for DEFB4A? 03/07/2021

Therapeutic strategies for DEFB4A include modulating its expression levels, enhancing its antimicrobial activity, and developing inhibitors targeting its signaling pathway. Treatment depends on the type and severity of the disease.

How can I detect the expression level of DEFB4A? 11/15/2020

The mRNA and protein expression levels of DEFB4A in tissues and cells can be detected by real-time PCR, immunohistochemistry, and western blotting.

What is the interaction between DEFB4A and other biomolecules? 02/01/2020

There are interactions between DEFB4A and other biomolecules. For example, it can bind to the cell membrane of pathogenic microorganisms and disrupt their integrity to exert antimicrobial effects, and it can also bind to receptors on the surface of epithelial cells to activate signal transduction pathways and regulate cellular immune responses.

Customer Reviews (3)

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Reviews
06/28/2023

    The structure is very stable and not easy to deteriorate.

    06/01/2023

      The cost is low and the activity is strong, which greatly saves our scientific research costs.

      04/09/2020

        The quality of the DEFB4A is very high, which makes my experiments more smooth and accurate.

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