Recombinant Human Defensin, Beta 4A
Cat.No. : | DEFB4A -5387H |
Product Overview : | Recombinant HumanDefensin beta 4 is a single, non-glycosylated polypeptide chain containing 50amino acids. |
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- Gene Information
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Cat. No. : | DEFB4A -5387H |
Description : | DEFB4A also known as skin-antimicrobial peptide 1(SAP1) is a peptide that in humans is encoded by the DEFB4 (defensin, beta 4)gene. Human DEFB4A is a cysteine-rich cationic low molecularweight antimicrobial peptide recently discovered in lesional skin. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from asterile filtered solution in 20 mM PBS, pH 7.4 + 130 mM NaCl. |
Molecular Weight : | 6.0 kDa |
Purity : | > 98% by HPLC andSDS-PAGE. |
Endotoxin Level : | < 0.1 ng/µg ofDefensin beta 4. |
Biological Activity : | Determined by itsability to chemoattract human monocytes using a concentration range of 0.1-50ng/mL. |
Sequence : | EFELDRICGYGTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP |
Reconstitution : | Centrifuge vialprior to opening. Add sterile distilled water or aqueous buffer to a concentrationof 0.1-1.0 mg/mL. Further dilutions should be made in appropriate bufferedsolutions. |
Storage : | Stable at 2-8°C, butbest kept desiccated -20°C. Upon reconstitution, stable for up to 1 week at2-8°C. For longer term, store in working aliquots below -20°C. Avoid repeatedfreeze/thaw cycles. |
OfficialSymbol : | DEFB4A |
Gene Name : | DEFB4A defensin, beta 4A [ Homosapiens ] |
Synonyms : | DEFB4A; defensin,beta 4A; BD-2; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102; hBD-2;beta-defensin 4A; Skin-antimicrobial peptide 1; defensin, beta 2; defensin,beta 4; OTTHUMP00000159651; skin-antimicrobial peptide 1; Defensin, beta 2;Skin-antimicrobial peptide 1 |
Gene ID : | 1673 |
mRNA Refseq : | NM_004942 |
Protein Refseq : | NP_004933 |
MIM : | 602215 |
UniProt ID : | O15263 |
Chromosome Location : | 8p23.1 |
Products Types
◆ Recombinant Protein | ||
DEFB4A-5133H | Recombinant Human DEFB4A Protein, GST-tagged | +Inquiry |
DEFB4A-133D | Active Recombinant Human DEFB4A Protein (50 aa) | +Inquiry |
DEFB4A-1064R | Recombinant Rhesus Macaque DEFB4A Protein, His (Fc)-Avi-tagged | +Inquiry |
DEFB4A-1333H | Recombinant Human DEFB4A Protein, His-tagged | +Inquiry |
DEFB4A-037H | Active Recombinant Human Defensin, Beta 4A | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionDEFB4A has a typical β-defensin structure consisting of a cysteine-rich mature peptide region and a positively charged N-terminal region. This structure allows it to bind and destroy the cell membranes of pathogenic microorganisms.
Biomolecules that can be used as molecular markers for DEFB4A include its mRNA and protein expression products in tissues and cells, as well as other biomolecules (e.g., receptors, signal transduction molecules, etc.) that interact with it.
The abnormal expression of DEFB4A is associated with a variety of inflammatory and infectious diseases, such as psoriasis, atopic dermatitis, chronic sinusitis, etc. In addition, the expression of DEFB4A has also been found to be associated with the occurrence and progression of certain tumors.
Therapeutic strategies for DEFB4A include modulating its expression levels, enhancing its antimicrobial activity, and developing inhibitors targeting its signaling pathway. Treatment depends on the type and severity of the disease.
The mRNA and protein expression levels of DEFB4A in tissues and cells can be detected by real-time PCR, immunohistochemistry, and western blotting.
There are interactions between DEFB4A and other biomolecules. For example, it can bind to the cell membrane of pathogenic microorganisms and disrupt their integrity to exert antimicrobial effects, and it can also bind to receptors on the surface of epithelial cells to activate signal transduction pathways and regulate cellular immune responses.
Customer Reviews (3)
Write a reviewThe structure is very stable and not easy to deteriorate.
The cost is low and the activity is strong, which greatly saves our scientific research costs.
The quality of the DEFB4A is very high, which makes my experiments more smooth and accurate.
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