Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged
Cat.No. : | FGFR2-5418H |
Product Overview : | Recombinant humanFGFR2 cytoplasmic domain (amino acids 403-822), His-tagged. No specialmeasures were taken to activate this kinase. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FGFR2-5418H |
Description : | This protein functions as amodifier of endothelial cell migration and proliferation, as well as anangiogenic factor. It acts as a mitogen for a variety of mesoderm- andneuroectoderm-derived cells in vitro, thus is thought to be involved inorganogenesis. Three alternatively spliced variants encoding differentisoforms have been described. The heparin-binding growth factors areangiogenic agents in vivo and are potent mitogens for a variety of cell typesin vitro. There are differences in the tissue distribution and concentrationof these 2 growth factors. |
Source : | Insect cells |
Species : | Human |
MolecularWeight : | 52.1 kDa |
Purity : | ≥ 90% as determinedby SDS-PAGE analysis |
Specific Activity : | 2700nmole of phosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute permg oftotalprotein at 30°C. Activity determined at a final protein concentration of 1μg/ml. |
Storage : | Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | FGFR2 |
Gene Name : | FGFR2 fibroblast growth factorreceptor 2 [ Homo sapiens ] |
Synonyms : | FGFR2; fibroblast growth factorreceptor 2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332;K-SAM; FLJ98662; FGFR2; KSAR; FGFR-2; KSAM; OTTHUMP00000020621;OTTHUMP00000020629; BEK fibroblast growth factor receptor; CD332 antigen; FGFreceptor; Jackson-Weiss syndrome; Keratinocyte growth factor receptor 2;bacteria-expressed kinase; craniofacial dysostosis 1; fibroblast growthfactor receptor 2; hydroxyaryl-protein kinase; keratinocyte growth factorreceptor; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4 |
Gene ID : | 2263 |
mRNA Refseq : | NM_000141 |
Protein Refseq : | NP_000132 |
MIM : | 176943 |
UniProt ID : | P21802 |
Chromosome Location : | 10q26 |
Pathway : | Angiogenesis;Downstream signaling of activated FGFR; Endocytosis; FGF signaling pathway;FGFR ligand binding and activation; FGFR2 ligand binding and activation;FRS2-mediated cascade; IRS-mediated signalling; Insulin receptor signallingcascade; MAPK signaling pathway; Negative regulation of FGFR signaling; PI-3Kcascade; Pathways in cancer; Regulation of Actin Cytoskeleton; SHC-mediatedcascade |
Function : | ATP binding; fibroblast growthfactor receptor activity; heparin binding; nucleotide binding; proteinbinding; receptor activity; transferase activity |
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◆ Lysates | ||
FGFR2-2578HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
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◆ Assay kits | ||
Kit-0341 | FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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