Recombinant Human Filaggrin
Cat.No. : | FLG-1220H |
Product Overview : | Recombinant human FLGis Expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FLG-1220H |
Description : | FLG are animportant class of the intermediate filament-associated proteins whichinterectwith keratin intermediate filaments (Ifs) of terminally differentiating mammalianepidermis. FLG exhibitwide species variations. FLG also appears to bea target molecula for rheumatoid arthritis-specific auto-antibodies inhumans. |
Source : | E. coli |
Species : | Human |
Form : | Recombinant Human FLGprotein (a.a.3838-4062) at 100 μg/ml in 50 mM Tris-Acetate + pH 7.5 + 1 mMEDTA + 20% Glycerol. |
Storage : | Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stablefor 12 months. Please avoid freeze-thaw cycles. |
OfficialSymbol : | FLG |
Gene Name : | FLG filaggrin [ Homo sapiens] |
Synonyms : | FLG; filaggrin; ATOD2;epidermal filaggrin; OTTHUMP00000014057 |
Gene ID : | 2312 |
mRNA Refseq : | NM_002016 |
Protein Refseq : | NP_002007 |
MIM : | 135940 |
UniProt ID : | P20930 |
Chromosome Location : | 1q21.3 |
Function : | calcium ion binding; structuralmolecule activity; nucleoside-triphosphatase activity |
Products Types
◆ Recombinant Protein | ||
FLG-2692H | Recombinant Human FLG protein(2441-2620 aa), C-His-tagged | +Inquiry |
FLG-1503H | Recombinant Human FLG Protein, His&GST-tagged | +Inquiry |
Flg-1625M | Recombinant Mouse Flg protein, His & GST-tagged | +Inquiry |
FLG-1221H | Recombinant Human FLG, GST-tagged | +Inquiry |
FLG-3361M | Recombinant Mouse FLG protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThere are currently no drugs that directly target FLG protein, but there are some drugs that can affect the expression level and activity of FLG protein, such as some growth factors and cytokines.
For atopic dermatitis caused by FLG gene mutations, treatments for inflammation and itching, such as topical glucocorticoids, antihistamines, etc., can also be used for systemic treatments, such as immunosuppressants and biologics.
Mutations in the FLG protein can cause abnormal keratin fiber structure in keratinocytes, affecting the maturation and differentiation of the stratum corneum, resulting in symptoms such as dryness, scaling, and itching.
Gene sequencing technology can be used to detect FLG gene mutations in patients with atopic dermatitis, so as to provide a basis for diagnosis and treatment.
Patients with atopic dermatitis often have mutations in the FLG gene, which lead to impaired skin barrier function, which in turn causes symptoms such as skin inflammation and itching.
Treatment of skin diseases caused by FLG protein mutations includes topical moisturizers, keratin softeners, and anti-inflammatory drugs, as well as systemic treatments such as oral medications, biologics, etc.
Customer Reviews (3)
Write a reviewCatalytic activity is excellent, and the catalytic performance is stable regardless of the environment
Will not interact with other reagents, will not affect.
The quality is very good, and their service life is very long, I am very satisfied with this product.
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