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Recombinant Human Filaggrin

Cat.No. : FLG-1220H
Product Overview : Recombinant human FLGis Expressed in E. coli.
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  • Gene Information
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Cat. No. : FLG-1220H
Description : FLG are animportant class of the intermediate filament-associated proteins whichinterectwith keratin intermediate filaments (Ifs) of terminally differentiating mammalianepidermis. FLG exhibitwide species variations. FLG also appears to bea target molecula for rheumatoid arthritis-specific auto-antibodies inhumans.
Source : E. coli
Species : Human
Form : Recombinant Human FLGprotein (a.a.3838-4062) at 100 μg/ml in 50 mM Tris-Acetate + pH 7.5 + 1 mMEDTA + 20% Glycerol.
Storage : Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stablefor 12 months. Please avoid freeze-thaw cycles.
OfficialSymbol : FLG
Gene Name : FLG filaggrin [ Homo sapiens]
Synonyms : FLG; filaggrin; ATOD2;epidermal filaggrin; OTTHUMP00000014057
Gene ID : 2312
mRNA Refseq : NM_002016
Protein Refseq : NP_002007
MIM : 135940
UniProt ID : P20930
Chromosome Location : 1q21.3
Function : calcium ion binding; structuralmolecule activity; nucleoside-triphosphatase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a drug that targets the FLG protein? 05/29/2022

There are currently no drugs that directly target FLG protein, but there are some drugs that can affect the expression level and activity of FLG protein, such as some growth factors and cytokines.

How is atopic dermatitis caused by FLG gene mutations treated? 12/19/2021

For atopic dermatitis caused by FLG gene mutations, treatments for inflammation and itching, such as topical glucocorticoids, antihistamines, etc., can also be used for systemic treatments, such as immunosuppressants and biologics.

How do mutations in the FLG protein cause skin diseases? 10/06/2021

Mutations in the FLG protein can cause abnormal keratin fiber structure in keratinocytes, affecting the maturation and differentiation of the stratum corneum, resulting in symptoms such as dryness, scaling, and itching.

Can genetic diagnostics be Used to identify FLG mutations in patients with atopic dermatitis? 03/26/2021

Gene sequencing technology can be used to detect FLG gene mutations in patients with atopic dermatitis, so as to provide a basis for diagnosis and treatment.

How is FLG protein related to atopic dermatitis? 02/24/2020

Patients with atopic dermatitis often have mutations in the FLG gene, which lead to impaired skin barrier function, which in turn causes symptoms such as skin inflammation and itching.

Can skin diseases caused by mutations in the FLG protein be treated? 12/02/2019

Treatment of skin diseases caused by FLG protein mutations includes topical moisturizers, keratin softeners, and anti-inflammatory drugs, as well as systemic treatments such as oral medications, biologics, etc.

Customer Reviews (3)

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Reviews
10/20/2022

    Catalytic activity is excellent, and the catalytic performance is stable regardless of the environment

    07/03/2021

      Will not interact with other reagents, will not affect.

      01/14/2021

        The quality is very good, and their service life is very long, I am very satisfied with this product.

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