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Recombinant Human EPH Receptor A3, His-tagged

Cat.No. : EPHA3-1880H
Product Overview : Recombinant humanEPHA3 cytoplasmic domain (aa 569-983) with His tag. Activated in vitro viaauto-phosphorylation.
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Cat. No. : EPHA3-1880H
Description : EPHA3 (ephrin type-Areceptor 3) is a protein that inhumans is encoded by the EPHA3 gene. This gene belongs to the ephrin receptorsubfamily of the protein-tyrosine kinase family. EPH and EPH-related receptorshave been implicated in mediating developmental events, particularly in thenervous system. Receptors in the EPH subfamily typically have a single kinasedomain and an extracellular region containing a Cys-rich domain and 2fibronectin type III repeats. The ephrin receptors are divided into 2 groupsbased on the similarity of their extracellular domain sequences and theiraffinities for binding ephrin-A and ephrin-B ligands.
Source : E. coli
Species : Human
Form : Liquid in 20 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol.
Molecular Weight : 50.8 kDa
Purity : ≥ 90% as determinedby SDS-PAGE analysis.
Specific Activity : 1000 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 1 μg/ml.
Concentration : 0.4 mg/ml
Storage : Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : EPHA3
Gene Name : EPHA3 EPH receptor A3 [ Homosapiens ]
Synonyms : EPHA3; EPH receptorA3; EK4;ETK; HEK; ETK1; HEK4; TYRO4; ephrin type-A receptor 3; EPH-like kinase 4;OTTHUMP00000213903; OTTHUMP00000213904; OTTHUMP00000213905; human embryokinase 1; eph-like tyrosine kinase 1; TYRO4 protein tyrosine kinase;tyrosine-protein kinase receptor ETK1
Gene ID : 2042
mRNA Refseq : NM_005233
Protein Refseq : NP_005224
MIM : 179611
UniProt ID : P29320
Chromosome Location : 3p11.2
Pathway : Axon guidance; EPHAforward signaling; EphrinA-EPHA pathway
Function : ATP binding;GPI-linked ephrin receptor activity; nucleotide binding; protein binding;receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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