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Recombinant Human Fas (TNF receptor superfamily, member 6)

Cat.No. : FAS-5411H
Product Overview : RecombinantHuman soluble FAS receptor is a 157 amino acid polypeptide corresponding tothe TNFR homologous cysteine rich extracellular domain Fas.
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Cat. No. : FAS-5411H
Description : The FAS is a deathreceptor on the surface of cells that leads to programmed cell death(apoptosis). It is one of two apoptosis pathways, the other being themitochondrial pathway. FasR is located on chromosome 10 in humans and 19 inmice. Similar sequences related by evolution are found in most mammals.
Source : E. coli
Species : Human
Form : Lyophilized withoutadditives.
Molecular Weight : 17.6 kDa
Endotoxin Level : <0.1 ng/pg of FASreceptor
Purity : >95% asdetermined by SDS-PAGE and HPLC analyses.
Biological Activity : Determined by itsability to inhibit the cytotoxicity of Jurkat cells. The EDSO is between10-15 pg/ml in the presence of 2 ng/ml of human Fast.
Reconstitution : Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
Storage : Lyophilized proteinis stable for 2 years at -20°C. Reconstituted protein is stable for 1 week at2-4°C or for 3 months in working aliquots with a carrier protein (0.1%HSA orBSA) at -20°C. Please note that the addition of any carrier protein into thisproduct may produce unwanted endotoxin. This depends upon the particularapplication employed. Avoid repeated freeze-thaw cycles.
OfficialSymbol : FAS
Gene Name : FAS Fas (TNF receptorsuperfamily, member 6) [ Homo sapiens ]
Synonyms : FAS; Fas (TNFreceptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A;TNFRSF6; tumor necrosis factor receptorsuperfamily member 6; Fas AMA; FAS 827dupA; CD95 antigen; FASLG receptor;OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000217569;apoptosis antigen 1; Delta Fas/APO-1/CD95; APO-1 cell surface antigen;apoptosis-mediating surface antigen FAS; tumor necrosis factor receptorsuperfamily, member 6
Gene ID : 355
mRNA Refseq : NM_000043
Protein Refseq : NP_000034
MIM : 134637
UniProt ID : P25445
Chromosome Location : 10q24.1
Pathway : Activationof Pro-Caspase 8; Adipogenesis; African trypanosomiasis; Allograft rejection; Alzheimer"s disease; Apoptosis;Apoptosis Modulation by HSP70; Autoimmune thyroid disease; Caspase-8 is formed from procaspase-8; Chagas disease (American trypanosomiasis); Cytokine-cytokine receptor interaction; Death Receptor Signalling; Direct p53 effectors; FasL/ CD95L signaling; InfluenzaA
Function : binding;identical protein binding; kinase binding; protein binding; receptor activity;signal transducer activity; transmembrane signaling receptor activity; tumornecrosis factor-activated receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does FAS protein play a role in cell signaling? 10/30/2022

FAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.

Why apply knowledge of FAS proteins to clinical practice? 06/27/2022

It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.

How can diseases associated with FAS protein be prevented and treated? 05/13/2022

FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.

How can gene knockout or knockdown techniques be used to study the function of FAS proteins? 03/31/2021

Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.

What is the role of FAS protein in apoptosis? 09/29/2020

FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.

How can FAS protein be used to predict disease prognosis? 06/19/2020

The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.

Customer Reviews (3)

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Reviews
09/07/2022

    When experimenting with FAS, the results are very reproducible.

    07/29/2022

      The stability of FAS products allows them to cope with different experimental conditions and modes of operation.

      09/20/2021

        FAS has high specific activity and can exert strong biological effect at low concentration.

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