Catalog # or name ...
Recombinant humanBDNF is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 119amino acids.
BDNF, is a protein that,in humans, is encoded by the BDNF gene. BDNF is a member of the "neurotrophin"family of growth factors, which are related to the canonical "NerveGrowth Factor", NGF. Neurotrophic factors are found in the brain and theperiphery.
Lyophilized from asterile filtered solution after dialysis against 20 mM sodium citrate buffer,pH 5.0.
>96.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
<0.1 ng/ug ofBDNF
Determined by thedose-dependent induction of ACHE (acetylcholine esterase) in rat basalforebrain primary septal culture. The ED5O is 50 ng/ml.
Amino Acid Sequence
The sequence of thefirst five N-terminal amino acids is Met-His-Ser-Asp-Pro.
Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration not less than 100 pg/ml. Aftercomplete solubilization of the protein, it can be further diluted to otheraqueous solutions.
Store lyophilizedprotein at -20oC to -80oC. Reconstituted protein is stable for 1 week at2-4oC. For long term storage, aliquot and store at -20oC to -80oC with acarrier protein (0.1%HSA or BSA) as a stabilizer. Please note that the additionof any carrier protein into this product may produce unwanted endotoxin. Thisdepends upon the particular application employed. Avoid repeated freeze-thawcycles.
BDNF brain-derived neurotrophicfactor [ Homo sapiens ]
BDNF; brain-derivedneurotrophic factor; MGC34632; brain-derivedneurotrophic factor; abrineurin; neurotrophin; OTTHUMP00000232005;OTTHUMP00000232006; OTTHUMP00000232013; OTTHUMP00000232014;OTTHUMP00000232015; OTTHUMP00000232016; OTTHUMP00000232018;OTTHUMP00000232019; OTTHUMP00000232020; OTTHUMP00000232021;OTTHUMP00000232022; OTTHUMP00000232039; OTTHUMP00000232040;OTTHUMP00000232041; OTTHUMP00000232043
Huntington"sdisease;MAPK signaling pathway; Neurotrophic factor-mediated Trk receptor signaling;Neurotrophin signaling pathway; p75(NTR)-mediated signaling
PDBrendering based on 1bnd.
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