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Recombinant Macaca mulatta Interleukin 8

Cat.No. : IL8-5434M
Product Overview : Recombinant RhesusMonkey IL8 is expressed in E. coli.
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  • Gene Information
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Cat. No. : IL8-5434M
Description : IL8, also named CXCL8, monocyte-derivedneutrophil chemotactic factor (MDNCF), neutrophil-activating protein 1(NAP1), neutrophil-activating factor (NAF) and granulocyte chemotacticpeptide (GCP), belongs to the Glu-Leu-Arg motif containing (ELR+)CXC chemokine family and has been designated CXCL8. IL8 is a potentneutrophil chemoattractant that recruits neutrophils to sites ofinflammation. IL8 also activates neutrophil functions and promotesangiogenesis.
Source : E. coli
Species : Macaca mulatta
Form : Lyophilized from a0.2µm filtered concentrated solution in PBS, pH 7.4.
MolecularWeight : Approximately 9.1kDa, a single non-glycosylated polypeptide chain containing 79 amino acids.
Purity : > 97% by SDS-PAGEand HPLC analyses
Endotoxin Level : Less than 1EU/µg ofrRh IL8 as determined by LAL method.
Biological Activity : Determined by itsability to chemoattract human peripheral blood neutrophils using aconcentration range of 25-150 ng/ml.
Sequences : AVLPRSAKELRCECIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE PWVQRVVEKF VKRAENQNP
Reconstitution : We recommend thatthis vial be briefly centrifuged prior to opening to bring the contents tothe bottom. Reconstitute in sterile distilled water or aqueous buffercontaining 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutionsshould be apportioned into working aliquots and stored at ≤-20°C. Furtherdilutions should be made in appropriate buffered solutions.
Storage : This lyophilizedpreparation is stable at 2-8°C, but should be kept at -20°C for long termstorage, preferably desiccated. Upon reconstitution, the preparation isstable for up to one week at 2-8°C. For maximal stability, apportion thereconstituted preparation into working aliquots and store at -20°C to -80°C.Avoid repeated freeze/thaw cycles.
OfficialSymbol : IL8
Gene Name : IL8 interleukin 8 [ Macacamulatta ]
Synonyms : IL8; interleukin 8;interleukin-8; IL-8; C-X-C motif chemokine 8
Gene ID : 613028
mRNA Refseq : NM_001032965
Protein Refseq : NP_001028137
UniProt ID : P67813
Chromosome Location : 5
Pathway : Amoebiasis; Bladder cancer; Chemokinesignaling pathway; Cytokine-cytokine receptor interaction; Hepatitis C; HepatitisA; Legionellosis; Malaria; NOD-like receptor signaling pathway; Pathways incancer; Pertussis; RIG-I-like receptor signaling pathway; Rheumatoidarthritis; Salmonella infection; Toll-like receptor signaling pathway

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of IL8 in the immune system? 08/31/2021

Acts as a chemical messenger in the immune system that regulates inflammation and attracts immune cells such as white blood cells.

How about the effect of IL8 on tumor? 06/01/2020

Regulating tumor microenvironment, promoting tumor growth and metastasis, and can be used in tumor therapy research.

What is the relationship between IL8 and inflammatory response? 01/18/2020

IL8 plays a role in regulating and promoting the migration and activation of inflammatory cells in the inflammatory response.

Which diseases can be treated with IL8? 12/02/2019

Can be used to treat inflammatory diseases (such as rheumatoid arthritis, psoriasis), tumors (such as lung cancer, breast cancer) and other diseases.

Is IL8 relevant to immunotherapy? 03/18/2019

Yes, IL8 is closely related to immunotherapy, which can enhance the role of the immune system and assist in the treatment of certain diseases.

By what method is IL8 generally prepared? 02/03/2019

IL8 is generally prepared by gene recombination technology, and the IL8 gene is introduced into the appropriate expression system, and then expressed and purified.

Customer Reviews (3)

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Reviews
10/28/2022

    IL8 has good fluorescence and absorption properties.

    11/29/2020

      NIPBL has good stability in different environments and is not easy to degrade.

      04/17/2019

        Through animal models or in vitro experiments to evaluate the mechanism of the recombinant protein in related diseases, we found that the effect is very good.

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