Recombinant Human IL2-Inducible T-Cell Kinase, GST-tagged
Cat.No. : |
ITK-5438H |
Product Overview : |
Recombinanthuman full length ITK, GST-tagged. Activated in vitro viaauto-phosphorylation. |
- Specification
- Gene Information
- Related Products
Cat. No. : |
ITK-5438H |
Description : |
ITK is a member of the TEC family of non-receptor tyrosinekinases. ITK is expressed in T-cells and is important for T-cell developmentand activation through the antigen receptor. ITK require prior activation ofLck, Zap-70 and PI3-kinase for efficient activation and shares major substrateswith both Lck and Zap-70. ITK knockout mice show multiple effects on T celldevelopment, cytokine production and T-helper cell differentiation. T cellsthat lack or express mutant versions of ITK show impaired TCR-induced actinpolymerization, cell polarization and regulation of the signaling eventsinvolved in cytoskeletal reorganization. |
Source : |
Insect cells |
Species : |
Human |
Form : |
Liquidin 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol. |
Molecular Weight : |
99.9kDa |
Storage : |
Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : |
ITK |
Gene Name : |
ITKIL2-inducible T-cell kinase [ Homo sapiens ] |
Synonyms : |
ITK; IL2-inducible T-cell kinase; EMT; LYK; PSCTK2; MGC126257;MGC126258; tyrosine-protein kinase LYK; homolog of mouse T-cell itk/tsk;tyrosine-protein kinase ITK/TSK; EC 2.7.10.2; Kinase EMT |
Gene ID : |
3702 |
mRNA Refseq : |
NM_005546 |
Protein Refseq : |
NP_005537 |
MIM : |
186973 |
UniProt ID : |
Q08881 |
Chromosome Location : |
5q31-q32 |
Pathway : |
Chemokine signaling pathway;Leukocyte transendothelial migration; T cell receptor signaling pathway; AdaptiveImmune System; B Cell Receptor Signaling Pathway; Class I PI3K signaling events;Fc-epsilon receptor I signaling in mast cells |
Function : |
ATP binding; metal ion binding;non-membrane spanning protein tyrosine kinase activity; nucleotide binding;protein binding; transferase activity; zinc ion binding |
Products Types
Related Gene
ITK
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.