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Active Recombinant Mouse Neuroblastoma, Suppression Of Tumorigenicity 1, His-tagged

Cat.No. : Nbl1-5690M
Product Overview : Recombinant Mouse Nbl1protein was expressed in Murine myeloma cell line with a C-terminal Ile and10-His tag. Ala17-Asp178.
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Cat. No. : Nbl1-5690M
Description : Nbl1 was initiallyidentified as a gene whose expression is downregulated in srctransformed ratfibroblasts. Nbl1 has now been shown to be a prototypical member of the Nbl1family of secreted glycoproteins that are putative BMP antagonists. Nbl1family members share a cysteine-rich domain that is structurally related tothe cysteine knot motif found in TGFβ superfamily ligands. There are at leastfive mouse Nbl1 family members, including Nbl1, Gremlin/DRM, Cer1, Dante andPRDC. Additional Nbl1 family members include Xenopus Cerberus, chick Caronte,and C. elegans CeCan 1.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in PBS with BSA as a carrier protein.
N-terminalSequence : Ala17
Molecular Weight : 18.9 kDa
Activity : Measuredby its ability to bind rhBMP4 in a functional ELISA. Immobilized rmNbl1 at 2 μg/mL (100 μL/well) can bind rhBMP4 with a linearrange of 0.1-10 ng/mL.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 27-30kDa, reducing conditions.
Purity : >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 10 μg/mLin sterile PBS that containing at least 0.1% human or bovine serum albumin.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.
Gene Name : Nbl1 neuroblastoma, suppressionof tumorigenicity 1 [ Mus musculus ]
Official Symbol : Nbl1
Synonyms : Nbl1; neuroblastoma,suppression of tumorigenicity 1; DAN; NO3; Dana; D4H1S1733E; MGC123430;neuroblastoma suppressor of tumorigenicity 1; N03; zinc finger protein DAN
Gene ID : 17965
mRNA Refseq : NM_008675
Protein Refseq : NP_032701
UniProt ID : Q61477
Chromosome Location : 4 D3; 4 70.0 cM

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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