Active Recombinant Mouse Growth Differentiation Factor 6

• Cat.No.: Gdf6-722M
• Product Overview: Recombinant Mouse Gdf6protein was expressed in E. coli. Thr335-Arg454.

Specification

• Cat. No.: Gdf6-722M
• Description: Gdf6, also known asbone morphogenetic protein 13 (BMP13) or cartilage-derived morphogeneticprotein 2 (CDMP2), is a member of the bone morphogenetic protein (BMP) familywhich belongs to the transforming growth factor β (TGFβ) superfamily. Themature Gdf6 with 120 amino acids is a homodimeric protein containing thecharacteristic seven conserved cysteine residues. Gdf5, Gdf6 and Gdf7, whichshare 80-86% identity, define a new subgroup within the BMP family.
• Source: E. coli-derived.
• Form: Lyophilized from a0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
• N-terminalSequence: Thr335
• Molecular Weight: 13.7 kDa
• Activity: Measuredby its ability to induce alkaline phosphatase production by ATDC5 mousechondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351. The ED50for this effect is typically 4-16 μg/mL.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• Purity: >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 300μg/mL in sterile 4 mM HCl that containing at least 0.1% human or bovine serumalbumin.
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.

Gene Information

• Gene Name: Gdf6 growth differentiationfactor 6 [ Mus musculus ]
• Official Symbol: Gdf6
• Synonyms: Gdf6; growthdifferentiation factor 6; BMP13; GDF16; growth/differentiation factor 6;GDF-6; growth differentiation factor 16; growth/differentiation factor 16
• Gene ID: 242316
• mRNA Refseq: NM_013526
• Protein Refseq: NP_038554
• UniProt ID: P43028
• Chromosome Location: 4 A1; 4
• Pathway: TGF-beta signalingpathway
• Function: cytokine activity;growth factor activity; protein homodimerization activity