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Active Recombinant Human Syndecan 3, His-tagged

Cat.No. : SDC3-504H
Product Overview : Recombinant Human SDC3protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Gln48-Lys383.
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Cat. No. : SDC3-504H
Description : SDC3, also calledN-syndecan, is one of four vertebrate syndecans that are principal carriersof heparan sulfate and chondroitin sulfate glycosaminoglycans. These type 1transmembrane proteins show conserved cytoplasmic domains and divergentextracellular domains. Human SDC3 is synthesized as a 442 amino acid (aa)core protein with a 44 aa signal sequence, a 343 aa extracellular domain, a21 aa transmembrane region and a 34 aa cytoplasmic tail with a binding sitefor PDZ domains.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Gln48 predicted
Molecular Weight : 35.5 kDa
Activity : Measuredby the ability of the immobilized protein to inhibit the adhesion of SAOS2human osteosarcoma cells to human Fibronectin. When 5 x 104 cells/well are added to human SDC3 and human Fibronectin (0.5 μg/mL) coated plates,cell adhesion is blocked in a dose dependent manner after 1 hour at 37°C. TheED50 for this effect is typically 2.5-10 μg/mL.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 100-150kDa, reducing conditions.
Purity : >85%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 200 μg/ mLin PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.
Gene Name : SDC3 syndecan 3 [ Homosapiens ]
Official Symbol : SDC3
Synonyms : SDC3; syndecan 3; SDCN;SYND3; syndecan-3; N-syndecan; syndecan neural type; syndecan proteoglycan 3;KIAA0468; OTTHUMP00000040577; syndecan 3 (N-syndecan)
Gene ID : 9672
mRNA Refseq : NM_014654
Protein Refseq : NP_055469
MIM : 186357
UniProt ID : O75056
Chromosome Location : 1pter-p22.3
Pathway : Cell adhesion molecules (CAMs);ECM-receptor interaction; Malaria; Proteogylcan syndecan-mediated signalingevents; Syndecan-3-mediated signaling events
Function : cytoskeletal protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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