| Cat. No. : |
Antxr2-558M |
| Description : |
Antxr2 is a widely expressedanthrax toxin receptor (ATR) family protein. Antxr2 is a ~55 kDa protein thatcontains a 31 amino acid (aa) signal sequence, a 287 aa extracellular domain(ECD), a 21 aa transmembrane sequence, and a 148 aa cytoplasmic domain. Unlikehuman Antxr2 which has four isoforms, only one sequence has been reported formouse Antxr2. The main functional domain of Antxr2 is an extracellularintegrinlike von Willebrand factor type A (VWA) domain with a metal ion dependentadhesion site (MIDAS), through which it adheres selectively to collagen typeIV and laminin. |
| Source : |
Mammalian cells |
| Form : |
Lyophilized from a0.2 μm filtered solution in PBS with BSA as a carrier protein. |
| N-terminalSequence : |
Gly26 |
| Molecular Weight : |
32 kDa |
| Activity : |
Measured by itsability to bind anthrax protective antigen (PA) in a functional ELISA. ImmobilizedPA at 1.5 μg/mL (100 μL/well) can bind rmCMG2 with a linear range of 0.08-5.0μg/mL. |
| Endotoxin Level : |
< 1.0EU per 1 μg of the protein by the LAL method. |
| SDS-PAGE : |
32-35kDa, reducing conditions. |
| Purity : |
> 95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Reconstitution : |
100μg/mL in sterile PBS. |
| Storage : |
Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. |
