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Active Recombinant Mouse Furin (paired basic amino acid cleaving enzyme)

Cat.No. : Furin-566M
Product Overview : Recombinantmouse Furin protein was expressed in Chinese Hamster Ovary cell line, CHO-derived,with an N-terminus human CD33 signal peptide and a C-terminal 10-His tag. Gln25-Glu714.
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Cat. No. : Furin-566M
Description : Furin is a member ofthe proprotein convertase (PC) family, which belongs to the subtilisinsuperfamily of serine proteases. As a cellular protease, Furin processes avariety of proproteins in secretory pathway compartments by cleaving after Arg-Xaa-Lys/Arg-Arg-like motifs, which usually reside at the end of the pro regions ofthese proproteins.
Source : Chinese HamsterOvary cell line, CHO-derived
Form : Supplied as a 0.2 μmfiltered solution in Tris, CaCl2, NaCl, Brij-35 and Glycerol.
N-terminal Sequence : Asp108, Cys198,Ser239, Glu684
Molecular Weight : 77 kDa
Activity : Measured by itsability to cleave the fluorogenic peptide substrate pERTKR-AMC. The specificactivity is > 150 pmoles/min/μg, as measured under the described conditions.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE : 60-80 kDa, reducingconditions
Purity : >95%, by SDS-PAGEunder reducing conditions and visualized by Colloidal Coomassie® Blue stainat 5 μg per lane.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3months, -20 to -70 °C under sterile conditions after reconstitution.
Gene Name : Furin furin (paired basic aminoacid cleaving enzyme) [ Mus musculus ]
Official Symbol : Furin
Synonyms : Furin; furin (pairedbasic amino acid cleaving enzyme); OTTMUSP00000036135; OTTMUSP00000036136;OTTMUSP00000036137; OTTMUSP00000036138; Fur; PACE; SPC1; Pcsk3; 9130404I01Rik;prohormone convertase 3; diabasic-processing enzyme; substilisin pro-proteinprocessing enzyme; proprotein convertase substilisin/kexin type 3; pariedbasic amino acid residue cleaving enzyme; paried basic amino acidresidue-cleaving enzyme; EC 3.4.21.75
Gene ID : 18550
mRNA Refseq : NM_001081454
Protein Refseq : NP_001074923
UniProt ID : P23188
Chromosome Location : 7
Pathway : Delta-Notch Signaling Pathway;Gamma-carboxylation, transport, and amino-terminal cleavage of proteins;Influenza A; Maturation of Notch precursor via proteolytic cleavage;Metabolism of proteins; NGF processing; PTM: gamma carboxylation, hypusineformation and arylsulfatase activation; Post-translational proteinmodification; Removal of aminoterminal propeptides from gamma-carboxylatedproteins; Signal Transduction, Signaling by Notch; Signaling by PDGF; Signalingby TGF beta; Signalling by NGF
Function : endopeptidase activity; hydrolase activity;metal ion binding; nerve growth factor binding; peptidase activity; peptidebinding; protease binding; protein binding; serine-type endopeptidaseactivity; serine-type endopeptidase inhibitor activity; serine-type peptidaseactivity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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10/10/2022

    The proteins purchased from your company are of very high quality and are suitable for WB experiments.

    02/04/2022

      High quality product at a good price, a satisfactory shopping experience.

      03/30/2021

        The staff were enthusiastic and proactive in communicating with me and solving many technical problems in a timely manner.

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