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Active Recombinant Human Fucosyltransferase 8 (alpha (1, 6) fucosyltransferase), His-tagged

Cat.No. : FUT8-577H
Product Overview : Recombinanthuman FUT8 protein was expressed in Chinese Hamster Ovary cell line, CHO-derived;with an N-terminus human CD33 signal sequence, and 6-His tag. Asp32-Lys575.
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Cat. No. : FUT8-577H
Description : FUT8 is frequentlyfound at terminal sites on various glycols and is essential for thegeneration of many sugar epitomes. Well known FUT8 containing glycols includeLewis and ABO blood group antigens. Lewis epitomes are key elements involvedin leukocyte homing and extravasations process, thus are essential forlymphocyte maturation and natural defense functions.
Source : Chinese HamsterOvary cell line, CHO-derived
Form : Supplied as a 0.2 μmfiltered solution in Tris and NaCl.
N-terminal Sequence : His
Molecular Weight : 64 kDa
Activity : Measured by itsability to hydrolyze the donor substrate GDP-fucose. The specific activity is> 0.75 pmole/min/μg, as measured under the described conditions.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE : 58-62 kDa, reducingconditions
Purity : >90%, by SDS-PAGEunder reducing conditions and visualized by Colloidal Coomassie Blue stain at5 μg per lane.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3months, -20 to -70 °C under sterile conditions after reconstitution.
Gene Name : FUT8 fucosyltransferase 8 (alpha(1, 6) fucosyltransferase) [ Homo sapiens ]
Official Symbol : FUT8
Synonyms : FUT8; fucosyltransferase8 (alpha (1, 6) fucosyltransferase); alpha-(1, 6)-fucosyltransferase;OTTHUMP00000245300; OTTHUMP00000245301; OTTHUMP00000245302; OTTHUMP00000245303;OTTHUMP00000245304; OTTHUMP00000245305; OTTHUMP00000245306; OTTHUMP00000245307;OTTHUMP00000183477; OTTHUMP00000183478; OTTHUMP00000245299; EC 2.4.1.68; Fucosyltransferase8; GDP-L-Fuc: N-acetyl-beta-D-glucosaminide alpha 1, 6-fucosyltransferase;GDP-fucose-glycoprotein fucosyltransferase; Glycoprotein; 6-alpha-L-fucosyltransferase;alpha1-6FucT; MGC26465
Gene ID : 2530
mRNA Refseq : NM_004480
Protein Refseq : NP_004471
MIM : 602589
UniProt ID : Q9BYC5
Chromosome Location : 14q24.3
Pathway : AsparagineN-linked glycosylation; Glycosaminoglycan biosynthesis-keratan sulfate;Metabolic pathways; Metabolism of proteins; N-Glycanbiosynthesis; N-glycan antennae elongation in the medial/trans-Golgi;N-glycan biosynthesis, complex type; N-glycan biosynthesis, complex type;Reactions specific to the complex N-glycan synthesis pathway; Transcriptionalmisregulation in cancer; Transport to the Golgi and subsequent modification
Function : SH3domain binding; glycoprotein 6-alpha-L-fucosyltransferase activity;transferase activity, transferring glycosyl groups

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can manipulating FUT8 protein have implications in cancer therapy? 03/27/2021

Yes, altering FUT8 activity can impact cancer cell growth and metastasis, making it a potential target for cancer therapies.

Are there any challenges in targeting FUT8 protein for therapeutic interventions? 08/23/2019

One challenge is the specificity of FUT8 inhibitors, ensuring they do not affect other essential glycosylation processes in the body.

Can FUT8 protein modifications be used as biomarkers for certain diseases? 11/30/2018

Yes, abnormal glycosylation patterns due to FUT8 alterations can serve as biomarkers for diseases like cancer, aiding in early diagnosis.

How does FUT8 protein impact the development of therapeutic antibodies? 11/05/2016

FUT8-mediated glycosylation of antibodies can enhance their stability and effector functions, making them more effective in treating diseases like cancer and autoimmune disorders.

Are there any diseases directly linked to FUT8 protein deficiency? 03/12/2016

Yes, deficiencies in FUT8 have been associated with certain types of cancers and developmental disorders.

Customer Reviews (3)

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Reviews
04/01/2021

    With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

    06/30/2020

      Researchers who have utilized the FUT8 protein laud its reliability and effectiveness in their studies.

      05/12/2017

        Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.

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