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Active Recombinant Human Frizzled Family Receptor 10, Fc-tagged

Cat.No. : FZD10-581H
Product Overview : RecombinantHuman FZD10 protein was expressed in Murine myeloma cell line with the Fcpart of IgG1 Pro100-Lys330 (C-terminus) and Human Frizzled 10Ile21Gly161 (N-terminus).
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Cat. No. : FZD10-581H
Description : FZD10 is a 68 kDa sevenpass transmembrane glycoprotein in the Frizzled family of Wnt receptors. The 205amino acid N-terminal extracellular region of FZD10 contains a cysteine-rich domainthat comprises the Wnt binding domain and mediates receptor oligomerization.
Source : Mammalian cells
Form : Supplied as a 0.2 μmfiltered solution in PBS.
N-terminal Sequence : Ile21
Molecular Weight : 43 kDa
Activity : Measured by itsbinding ability in a functional ELISA. Biotinylated rmWnt-5a immobilized on astreptavidincoated plate at 1 μg/mL can bind rhFrizzled-10/ Fc Chimera withan apparent Kd < 35 nM.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE : 56-58 kDa, reducingconditions
Purity : >90%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
Reconstitution : Reconstitute at 100μg/mL in sterile PBS.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to-70 °C under sterile conditions after reconstitution.
Gene Name : FZD10 frizzled family receptor10 [ Homo sapiens ]
Official Symbol : FZD10
Synonyms : FZD10;frizzled family receptor 10; frizzled (Drosophila) homolog 10; frizzled 10,seven transmembrane spanning receptor; frizzled homolog 10 (Drosophila);frizzled-10; CD350; CD 350; CD 350 antigen; FZ10; FZD 10; FzE7; hFz10;frizzled homolog 10; frizzled 10, seven transmembrane spanning receptor;Fz10; FZ-10; OTTHUMP00000238659
Gene ID : 11211
mRNA Refseq : NM_007197
Protein Refseq : NP_009128
MIM : 606147
UniProt ID : Q9ULW2
Chromosome Location : 12q24.33
Pathway : Basal cellcarcinoma; Class B/2 (Secretin family receptors); GPCR ligand binding; HTLV-Iinfection; Melanogenesis; Pathways in cancer; Signal Transduction; Signalingby GPCR; Wnt Signaling Pathway; Wnt signaling network
Function : G-protein coupledreceptor activity; PDZ domain binding; Wnt-activated receptor activity;Wnt-protein binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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