Active Recombinant Mouse Frizzled Homolog 8 (Drosophila), Fc-tagged
Cat.No. : | Fzd8-593M |
Product Overview : | RecombinantMouse Fzd8 protein was expressed in Murine myeloma cell line with the Fc partof Human IgG1 Pro100-Lys330 (C-terminus) and Mouse Frizzled-8 (Ala25-Pro173)&(Ala28-Pro173)(N-terminus). |
- Specification
- Gene Information
- Related Products
Cat. No. : | Fzd8-593M |
Description : | Fzd8 is one of atleast ten seventransmembrane (7TM) glycoprotein of the Frizzled family of Wntreceptors. Frizzled proteins are thought to be G-protein-coupled. Wnt engagement,with low density lipoprotein receptor related proteins LRP-5 or LRP-6 actingas co-receptors stabilizes β-catenin and promotes gene transcription that isimportant in development and tissue maintenance. |
Source : | Mammalian cells |
Form : | Supplied as a 0.2 μmfiltered solution in PBS. |
N-terminal Sequence : | Ala25 & Ala28 |
Molecular Weight : | 43 kDa |
Activity : | Measured by itsability to interfere with the axis-inducing activity of Xwnt-8 mRNA in early Xenopusembryos. In a population of embryos, addition of 1 ng of mouse Frizzled8/ FcChimera protein per embryo resulted in 50-100% reduction in the number ofsecondary axes produced by 10-20 pg of Xwnt-8 mRNA. Also measured by itsability to bind biotinylated rmWnt-5a in a functional ELISA with an estimatedKD < 1 nM. |
Endotoxin Level : | <1.0 EU per 1 μgof the protein by the LAL method. |
SDS-PAGE : | 59-60 kDa, reducingconditions |
Purity : | >95%, by SDS-PAGEunder reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstitute at 250μg/mL in sterile PBS. |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to-70 °C under sterile conditions after reconstitution. |
Gene Name : | Fzd8 frizzled homolog 8(Drosophila) [ Mus musculus ] |
Official Symbol : | Fzd8 |
Synonyms : | Fzd8;frizzled homolog 8 (Drosophila); Fz8; frizzled-8; Fz-8; mFz8 |
Gene ID : | 14370 |
mRNA Refseq : | NM_008058 |
Protein Refseq : | NP_032084 |
UniProt ID : | Q61091 |
Chromosome Location : | 18 |
Pathway : | Basal cellcarcinoma; Class B/2 (Secretin family receptors); GPCR ligand binding; HTLV-Iinfection; Melanogenesis; Pathways in cancer; Signal Transduction; Signalingby GPCR; Wnt Signaling Pathway; Wnt signaling network |
Function : | G-proteincoupled receptor activity; PDZ domain binding; Wnt-activated receptoractivity; Wnt-protein binding |
Products Types
◆ Recombinant Protein | ||
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FZD8-596H | Recombinant Human FZD8(Ala28-Pro172) Protein, C-6*His-tagged | +Inquiry |
FZD8-2432R | Recombinant Rat FZD8 Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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