Active Recombinant Human Meprin A, Beta, His-tagged
Cat.No. : | MEP1B-1980H |
Product Overview : | RecombinantHuman MEP1B protein was expressed in Murine myeloma cellline. Leu21-Ser593& Thr23-Ser593, both with a C-terminal 10-His tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | MEP1B-1980H |
Description : | Meprinsare multimeric proteases composed of α and β subunits, which are members ofthe astacin family of zinc endopeptidases. Both subunits form disulfide-linkedhomo-or eterooligomers, which are also referred to as Merpin A (composed of αsubunits with or without β subunits) and MEP1B (composedof β subunits only). Although the two subunits share 42% identity in theiramino acid sequence, they differ significantly in their oligomeric structure,posttranslational processing and subsequently cellular location, andsubstrate and peptide bond specificity. |
Source : | Mammalian cells |
Form : | Supplied as a 0.2 μmfiltered solution in Tris, NaCl and Glycerol. |
N-terminalSequence : | Leu21 & Thr23 |
MolecularWeight : | 66 kDa |
Activity : | Measuredby its ability to cleave a fluorogenic peptide substrate, McaSEVNLDAEFRK(Dpn)RR-NH2,The specific activity is > 350 pmoles/min/μg, as measured under thedescribed conditions. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 85 kDa,reducing conditions. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening. |
Gene Name : | MEP1B meprin A, beta [ Homosapiens ] |
Official Symbol : | MEP1B |
Synonyms : | MEP1B; meprin A,beta; meprin A subunit beta; PPH beta; meprin B; endopeptidase-2; PABApeptide hydrolase; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunitbeta; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; EC 3.4.24.63 |
Gene ID : | 4225 |
mRNA Refseq : | NM_005925 |
Protein Refseq : | NP_005916 |
MIM : | 600389 |
UniProt ID : | Q16820 |
Chromosome Location : | 18q12.2-q12.3 |
Pathway : | Protein digestion and absorption |
Function : | metal ion binding; metalloendopeptidaseactivity; peptidase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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