Active Recombinant Mouse Glycoprotein 6 (platelet), His-tagged
Cat.No. : | Gp6-5622M |
Product Overview : | RecombinantMouse Gp6 protein was expressed in Murine myeloma cell line. Met1-Lys265,with a C-terminal 6-His tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Gp6-5622M |
Description : | Gp6 is a63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein ofthe immunoglobulin superfamily that is an important collagen receptor andinitiator of platelet activation, aggregation and thrombus generation. Gp6 isalso a secondary receptor required for platelet spreading on laminin. Mouse Gp6contains a 21 amino acid (aa) signal sequence, a 244 aa extracellular domain (ECD)that has two C-type Ig-like domains followed by a mucin-like, presumablyO-glycosylated Ser-Thr-rich region, a 21 aa transmembrane (TM) domain and a27 aa cytoplasmic tail. Mouse Gp6 ECD shares 70%, 85%, 69% and 66% aaidentity with human, rat, equine and canine Gp6 ECD, respectively. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 um filtered solution in PBS. |
N-terminalSequence : | Gly24 |
MolecularWeight : | 27.8 kDa (monomer) |
Activity : | Measuredby its binding ability in a functional ELISA. When cross-linked with 10 μg/mLof Mouse polyHistidine Monoclonal Antibody. Recombinant Mouse Gp6 binds toCollagen I (coated at 10 μg/mL, 100 μL/well) with an apparent KD < 90 nM. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 45-60kDa, reducing conditions. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstituteat 400μg/mL in PBS. |
Storage : | Use a manual defrost freezer and avoid repeated freezethawcycles. 12months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °Cunder sterile conditions after reconstitution. 3 months, -20 to -70 °C understerile conditions after reconstitution. |
Gene Name : | Gp6 glycoprotein 6 (platelet) [ Mus musculus ] |
Official Symbol : | Gp6 |
Synonyms : | Gp6; glycoprotein6 (platelet); Gpvi; Gm469; 9830166G18Rik; platelet glycoprotein VI;glycoprotein 5 |
Gene ID : | 243816 |
mRNA Refseq : | NM_001163014 |
Protein Refseq : | NP_001156486 |
UniProt ID : | P0C191 |
Chromosome Location : | 7 |
Pathway : | Cell surfaceinteractions at the vascular wall; ECM-receptor interaction; GPVI-mediatedactivation cascade; Hemostasis; Platelet Adhesion to exposed collagen; Plateletactivation |
Function : | collagen binding; receptoractivity |
Products Types
◆ Recombinant Protein | ||
GP6-3054H | Recombinant Human GP6 Protein, His (Fc)-Avi-tagged | +Inquiry |
Gp6-3808M | Recombinant Mouse Gp6 Protein, His (Fc)-Avi-tagged | +Inquiry |
GP6-2611M | Recombinant Mouse GP6 Protein (22-265 aa), His-SUMO-tagged | +Inquiry |
GP6-5623H | Active Recombinant Human Glycoprotein 6 (platelet), His-tagged | +Inquiry |
Gp6-361M | Active Recombinant Mouse Gp6, His-tagged | +Inquiry |
◆ Lysates | ||
GP6-5821HCL | Recombinant Human GP6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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