Active Recombinant Mouse Growth Hormone Receptor, Fc-tagged

• Cat.No.: Ghr-5620M
• Product Overview: Recombinant Mouse Ghrprotein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330and Thr25-Gln273 & Ile98-Gln273 (N-terminus).

Specification

• Cat. No.: Ghr-5620M
• Description: Ghr, also known assomatotropin, is a member of a family of growth factors that includesprolactin, placental lactogens, proliferins and somatolactin. It issynthesized primarily by somatotropes in the anterior pituitary and isreleased as an endocrine hormone. Other cells and tissues, including lymphoidtissues, can also produce Ghr. Ghr is a pleiotropic molecule which can actdirectly or indirectly via IGFI to regulate growth and metabolism as well asenhance T cell survival and thymic functions.
• Source: Mammalian cells
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminalSequence: Thr25 & Ile98
• Molecular Weight: 55.4 kDa
• Activity: Measuredby its ability to inhibit Ghinduced proliferation of Nb2-11 rat lymphomacells. Gout, P.W. et al. (1980) Cancer Res. 40:2433. The ED50 for this effectis typically 4-16 ng/mL in the presence of 0.2 ng/mL of rhGhr.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 70-75kDa, reducing conditions
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
• Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Ghr growth hormone receptor [Mus musculus ]
• Official Symbol: Ghr
• Synonyms: Ghr;growth hormone receptor; GHBP; GHR/BP; AA986417; GH receptor; somatotropinreceptor; growth hormone receptor/binding protein; Growth hormone receptorprecursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein);Uncharacterized protein; mCG_141048
• Gene ID: 14600
• mRNA Refseq: NM_010284
• Protein Refseq: NP_034414
• UniProt ID: Q3UP14
• Chromosome Location: 15 A1; 15 4.6 cM
• Pathway: Androgen Receptor SignalingPathway; Cytokine-cytokine receptor interaction; Endochondral Ossification;Jak-STAT signaling pathway; Neuroactive ligand-receptor interaction
• Function: SH2 domain binding;cytokine receptor activity; growth factor binding; growth hormone receptoractivity; peptide hormone binding; protein binding; protein homodimerizationactivity; protein kinase binding; protein phosphatase binding; receptoractivity