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Active Recombinant Mouse Dickkopf Homolog 1 (Xenopus laevis)

Cat.No. : Dkk1-398M
Product Overview : Recombinant mouse Dkk1protein was expressed in Chinese Hamster Ovary cell line, CHO-derived. Ser30-His272.
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Cat. No. : Dkk1-398M
Description : Dkk1 is the foundingmember of the Dickkopf family of proteins that includes Dkk-1, -2, -3, -4, anda related protein, Soggy. Dkk proteins are secreted proteins that contain twoconserved cysteine-rich domains separated by a linker region. Each domaincontains ten cysteine residues. Mature mouse Dkk1 is a 40 kDa glycosylatedprotein that shares 86%, 96%, 83% and 82% amino acid (aa) sequence identitywith human, rat, rabbit and bovine Dkk1, respectively.
Source : Chinese HamsterOvary cell line, CHO-derived
Form : Lyophilizedfrom a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
N-terminal Sequence : Ser30 & Thr32
Molecular Weight : 26.1 kDa
Activity : Measured by itsability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3-E1mouse osteoblastic cells. The ND50 for this effect is typically0.02-0.1 μg/mL in the presence of 10 ng/mL of rmWnt-3a.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstitute at 100μg/mL in sterile PBS that containing at least 0.1% human or bovine serumalbumin.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name : Dkk1dickkopf homolog 1 (Xenopus laevis) [ Mus musculus ]
Official Symbol : Dkk1
Synonyms : Dkk1; dickkopfhomolog 1; mddk-1; OTTMUSP00000022079; dickkopf-related protein 1; dkk-1; dickkopf-1;mCG_6758
Gene ID : 13380
mRNA Refseq : NM_010051
Protein Refseq : NP_034181
UniProt ID : Q80UL5
Chromosome Location : 19
Pathway : Wnt SignalingPathway; PluriNetWork
Function : Low-density lipoprotein particle binding; receptorantagonist activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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