Active Recombinant Mouse A Disintegrin-Like And Metallopeptidase (reprolysin type) With Thrombospondin Type 1 Motif, 1, His-tagged
Cat.No. : | Adamts1-441M |
Product Overview : | RecombinantMouse Adamts1proteinwas expressed in Chinese Hamster Ovary cell line. Phe254-Cys725,with a C terminal 10 His tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Adamts1-441M |
Description : | Adamts1 is the foundingmember of the family of secreted zinc proteases with a multi domainstructure. The protein precursor consists of a signal peptide and the followingdomains: pro, catalytic, disintegrinlike, TS type 1 motif, cysteine rich,spacer and a variable number of thrombospondin type 1 Motifs. Based on theirsubstrate specificity, Adamts1 and associated familymembers may be key enzymes in the degradation of cartilage leading toinflammation and arthritis. |
Source : | ChineseHamster Ovary cell line, CHO-derived. |
Form : | Monomer.Recombinant Mouse Adamts1 is prone to proteolytic cleavage at C terminus.The predominant form of the purified protein lacks the His tag. |
N-terminalSequence : | Phe254 |
MolecularWeight : | 53 kDa |
Activity : | Measuredby its ability to cleave rhAggrecan. rm Adamts1 achieves > 50% substrate cleavage, as measured underthe described conditions. See Activity Assay Protocol. |
Endotoxin Level : | <1.0EU per 1 ug of the protein by the LAL method. |
Purity : | >95%,by SDSPAGE under reducing conditions and visualized by silver stain. |
Storage : | Use a manual defrost freezer and avoid repeated freezethawcycles.6 months from date of receipt, 20 to 70°C as supplied. 3 months, 20 to 70°Cunder sterile conditions after opening. |
Gene Name : | Adamts1 a disintegrin-like andmetallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 [ Musmusculus ] |
Official Symbol : | Adamts1 |
Synonyms : | Adamts1; a disintegrin-likeand metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1; C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1;ADAMTS-1; A disintegrin and metalloproteinase with thrombospondin motifs 1;ADAM-TS 1; a disintegrin-like and metalloprotease (reprolysin type) withthrombospondin type 1 motif, 1 |
Gene ID : | 11504 |
mRNA Refseq : | NM_009621 |
Protein Refseq : | NP_033751 |
UniProt ID : | P97857 |
Chromosome Location : | 16 |
Pathway : | Endochondral Ossification |
Function : | heparin binding; hydrolaseactivity; metal ion binding; metalloendopeptidase activity; metallopeptidaseactivity; peptidase activity; protein binding; zinc ion binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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