Active Recombinant Mouse Adhesion Molecule, Interacts With CXADR Antigen 1
Cat.No. : | Amica1-447M |
Product Overview : | Recombinant Mouse Amica1protein was expressed in Murine myeloma cell line. Leu23-Leu281. |
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- Gene Information
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Cat. No. : | Amica1-447M |
Description : | Amica1 is a 65kDa, type I transmembrane glycoprotein that belongs to the junctionaladhesion molecule (JAM) subset of the immunoglobulin superfamily. JAM familyproteins contribute to intercellular connections within epithelial andendothelial cell layers and mediate their interactions with varioushemopoietic cells. The mouse Amica1 cDNA encodes a 379amino acid (aa) precursor that includes a 20 aa signal sequence, a 261 aaextracellular domain (ECD) with two Iglike domains, a 21 aa transmembranesegment, and a 77 aa cytoplasmic domain. In contrast to other JAM familyproteins, AMICA does not contain a cytoplasmic PDZ binding motif. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 um filtered solution in PBS. |
N-terminalSequence : | Leu23 |
MolecularWeight : | 56.6 kDa (monomer) |
Activity : | Measuredby the ability of the immobilized protein to support the adhesion of human neutrophils.When 2 x 105 cells/well are added to rmAMICAcoated plates (10 μg/mL, 100μL/well), 30 50% of the cells will adhere after 20 minutes at 37°C. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
Purity : | >95%,by SDSPAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstitute at 100μg/mLin sterile PBS. |
Storage : | Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, 20 to 70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, 20 to 70°C under sterile conditions after reconstitution. |
Gene Name : | Amica1 adhesion molecule,interacts with CXADR antigen 1 [ Mus musculus ] |
Official Symbol : | Amica1 |
Synonyms : | Amica1; adhesionmolecule, interacts with CXADR antigen 1; AMICA; Crea7; Gm638;junctional adhesion molecule-like; mCrea7; adhesion molecule AMICA; dendriticcell-specific protein CREA7; dendritic-cell specific protein Crea7 |
Gene ID : | 270152 |
mRNA Refseq : | NM_001005421 |
Protein Refseq : | NP_001005421 |
UniProt ID : | Q80UL9 |
Chromosome Location : | 9 |
Function : | cell adhesionmolecule binding |
Products Types
◆ Recombinant Protein | ||
AMICA1-11H | Recombinant Human AMICA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Jaml-3631M | Recombinant Mouse Jaml Protein, Myc/DDK-tagged | +Inquiry |
JAML-789H | Recombinant Human JAML Protein, MYC/DDK-tagged | +Inquiry |
AMICA1-142R | Recombinant Rhesus Macaque AMICA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Amica1-973M | Recombinant Mouse Amica1 protein(Met1-Leu281), hFc-tagged | +Inquiry |
◆ Lysates | ||
AMICA1-2634HCL | Recombinant Human AMICA1 cell lysate | +Inquiry |
AMICA1-001MCL | Recombinant Mouse AMICA1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionActivation of AMICA1 triggers downstream signaling pathways, such as Rho GTPases, PI3K/AKT, or MAPK/ERK, which modulate cytoskeletal rearrangement, cell survival, and gene expression, impacting cellular functions.
AMICA1 contributes to the formation and maintenance of tissue architecture by promoting cell adhesion, regulating cell polarity, and facilitating tissue-specific cellular organization.
AMICA1 exhibits a tissue-specific expression pattern, with higher expression observed in epithelial tissues, neural tissues, and certain organs like the liver and kidney.
Targeting AMICA1 signaling or interaction with specific antibodies or small molecules holds potential as a therapeutic strategy for diseases associated with abnormal cell adhesion or tissue integrity.
AMICA1 interacts with various cell adhesion molecules, such as cadherins, integrins, or selectins, as well as extracellular matrix components like collagen or fibronectin, facilitating cell-cell and cell-matrix interactions.
AMICA1 can undergo post-translational modifications, including phosphorylation, glycosylation, or ubiquitination, which can affect its adhesive properties, intracellular signaling, or protein stability.
During development and tissue regeneration, AMICA1 expression is dynamically regulated, showing distinct spatiotemporal patterns that coincide with tissue remodeling and organogenesis.
AMICA1 plays a crucial role in cell-cell adhesion and cell migration processes, promoting the formation of stable intercellular junctions and regulating cellular movement and tissue morphogenesis.
Dysregulation of AMICA1 expression or function has been implicated in various diseases, including cancer metastasis, epithelial barrier dysfunction, or neurodevelopmental disorders, underscoring its involvement in disease pathogenesis.
Modulation of AMICA1 expression or activity can influence cellular phenotypes, including cell proliferation, differentiation, and cell fate determination, highlighting its role in tissue homeostasis and development.
Customer Reviews (3)
Write a reviewCompatibility with complex biological matrices for translational research.
Enhanced assay sensitivity for detection of subtle protein changes.
Accurate determination of protein function and activity.
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