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Active Recombinant Mouse V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Fc-tagged

Cat.No. : Erbb3-470M
Product Overview : Recombinant Mouse Erbb3protein was expressed in Murine myeloma cell line with the Fc part of mouse IgG2a.Ser20-His641.
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Cat. No. : Erbb3-470M
Description : Erbb3, also called HER3(human epidermal growth factor receptor 3) in humans, is a type I transmembraneglycoprotein that is a member of the ErbB family of tyrosine kinase receptorsnamed for a viral oncogene. ErbB family members serve as receptors for the EGFfamily of growth factors. Mouse Erbb3 contains a 19 amino acid (aa) signal sequence,a 622 aa extracellular domain (ECD), a 24 aa transmembrane region, and a 677 aacytoplasmic domain.
Source : Mammalian cells
Form : Lyophilized from a 0.2μm filtered solution in PBS.
N-terminalSequence : Ser20
Molecular Weight : 95.6 kDa
Activity : Measuredby its ability to bind rhNRG1ß1 extracellular domain in a functional ELISA withan estimated KD < 15 nM.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100 μg/mL in sterile PBS
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution.
Gene Name : Erbb3 v-erb-b2 erythroblastic leukemiaviral oncogene homolog 3 (avian) [ Mus musculus ]
Official Symbol : Erbb3
Synonyms : Erbb3; v-erb-b2erythroblastic leukemia viral oncogene homolog 3 (avian); Her3; C76256; Erbb-3;Erbb3r; receptor tyrosine-protein kinase erbB-3; c-erbB-3; receptor tyrosine kinase;glial growth factor receptor; proto-oncogene-like protein c-ErbB-3; avian erythroblastosisoncogene B 3 receptor; EC 2.7.10.1
Gene ID : 13867
mRNA Refseq : NM_010153
Protein Refseq : NP_034283
UniProt ID : Q61526
Chromosome Location : 10 D3; 10 70.0 cM
Pathway : Calcium signaling pathway;Endocytosis; ErbB signaling pathway; IL-6 signaling Pathway
Function : ATP binding; growth factorbinding; kinase activity; nucleotide binding; protein binding; protein heterodimerizationactivity; protein kinase activity; protein tyrosine kinase activator activity;NOT protein tyrosine kinase activity; receptor activity; receptor signaling proteintyrosine kinase activity; transferase activity; transferase activity; transmembranereceptor protein tyrosine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential side effects of targeting ERBB3 in cancer therapy? 03/08/2023

Potential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.

How does ERBB3 contribute to resistance to certain cancer therapies? 01/29/2023

ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.

How does ERBB3 interact with other receptors in the EGFR family? 11/07/2022

ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.

Can ERBB3 be used as a biomarker for prognosis in cancer patients? 10/26/2022

Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.

In which types of cancers is ERBB3 commonly overexpressed? 10/19/2020

ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.

Customer Reviews (3)

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Reviews
10/28/2021

    Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

    08/11/2021

      Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

      03/03/2020

        The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

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