"TPMT" Related Products

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Mouse Anti-Human TPMT Monoclonal Antibody

Cat. No.: CAB-11471MH
Product Overview: Anti-human TPMT mAb,is derived from hybridization of mouse F0 myeloma cells with spleen cellsfrom BALB/c mice immunized with a recombinant human TPMT protein.
Antigen Description: TPMT (ThiopurineS-methyltransferase) is a very important enzyme for the metabolizm ofthiopurine compounds. TPMT pharmacogenetics has been studied extensivelybecause of its clinical significance. Many patients got benefited from theknowledge of TPMT genotype-phenotype correlation. Also, TPMT activityexhibits autosomal codominant genetic polymorphism, and patients inheritingTPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.
Immunogen: Recombinant humanTPMT (1-245aa) purified from E. coli.
Host: Mouse
Isotype: Mouse IgG1heavy chain and κ light chain.
Application: ELISA; WB
Clone: BU3F8
Description: TPMT isan enzyme that methylates thiopurine compounds. The methyl donor isS-adenosyl-L-methionine, which is converted to S-adenosyl-L-homocysteine.
Concentration: 1 mg/ml
Form: Liquid.In Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
Usage: Theantibody has been tested by ELISA, Western blot analysis to assurespecificity and reactivity. Since application varies, however, eachinvestigation should be titrated by the reagent to obtain optimal results.Recommended dilution range for Western blot analysis is 1:1000.
Storage: Can bestored at +4°C. For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
Gene Name: TPMT thiopurineS-methyltransferase [ Homo sapiens ]
Official Symbol: TPMT
Synonyms: TPMT; thiopurine S-methyltransferase; S-adenosyl-L-methionine:thiopurineS-methyltransferase; EC 2.1.1.67; Thiopurine methyltransferase;OTTHUMP00000016076
Gene ID: 7172
mRNA Refseq: NM_000367
Protein Refseq: NP_000358
MIM: 187680
UniProt ID: P51580
Chromosome Location: 6p22.3
Pathway: Biological oxidations; Drugmetabolism - other enzymes; Metabolism; Phase II conjug
Function: methyltransferase activity;thiopurine S-methyltransferase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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