Recombinant Murine BMP4
Cat.No. : | Bmp4-578TM |
Product Overview : | Recombinant Murine BMP4 encoding murine BMP4 was expressedin E.coli. |
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- Gene Information
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Cat. No. : | Bmp4-578TM |
Description : | Bone morphogenetic proteins (BMPs) constitute a subfamilywithin the TGF-β superfamily of structurally related signaling proteins.Members of this superfamily are widely distributed throughout the body andare involved in diverse physiological processes during both pre- andpostnatal life. Like BMP-7, BMP-4 is involved in the development and maintenanceof bone and cartilage. Reduced expression of BMP-4 is associated with anumber of bone diseases, including the heritable disorder FibrodysplasiaOssificans Progressiva. PeproTech's E.coli derived murine BMP-4 is a fullyactive homodimeric protein consisting of two 106 amino acid subunits whichcorrespond to amino acids 303-408 of the full length BMP-4 precursor. |
Source : | E.coli |
Biological Activity : | Determined by its ability to induce alkaline phosphataseproduction by ATDC-5 cells. The expected ED50 for this effect is 5-15 ng/ml. |
AA Sequence : | KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNSTNHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCRKKNK NCRRHSLYVDFSDVGWNDWI VAPPGYQAFY CHGDCPFPLA DHLNSTNHAI VQTLVNSVNS SIPKACCVPT ELSAISMLYLDEYDKVVLKN YQEMVVEGCG CR |
Purity : | Greater than 98% by SDS-PAGE gel and HPLC analyses. |
Gene Name : | Bmp4 bonemorphogenetic protein4 [ Mus musculus ] |
Official Symbol : | Bmp4 |
Synonyms : | Bmp4; bonemorphogenetic protein 4; Bmp-4; Bmp2b; Bmp2b1;Bmp2b-1; BMP-2B; bonemorphogenetic protein 2B |
Gene ID : | 12159 |
mRNA Refseq : | NM_007554 |
Protein Refseq : | NP_031580 |
UniProt ID : | Q3ULR1 |
Chromosome Location : | 14 C1 |
Pathway : | Adipogenesis; Basalcell carcinoma; ESCPluripotency Pathways; Hedgehog signaling pathway;Pathways in cancer; PluriNetWork;TGF Beta Signaling Pathway; TGF-betasignaling pathway |
Function : | BMP receptor binding; chemoattractant activity;cytokine activity; growth factor activity; heparinbinding; protein binding;protein homodimerization activity |
Products Types
◆ Recombinant Protein | ||
BMP4-001H | Recombinant Human BMP4 Protein, His-MBP-tagged | +Inquiry |
BMP4-4364H | Recombinant Human BMP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
BMP4-11H | Active Recombinant Human BMP4 Protein, Pre-aliquoted | +Inquiry |
bmp4-322Z | Recombinant Zebrafish bmp4 Protein, His-tagged | +Inquiry |
Bmp4-14M | Recombinant Active Mouse BMP4 Protein, His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
BMP4-8432HCL | Recombinant Human BMP4 293 Cell Lysate | +Inquiry |
BMP4-8431HCL | Recombinant Human BMP4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionBMP4 can be used in spinal fusion surgery to stimulate bone growth and fuse vertebrae together, which can alleviate back pain and stabilize the spine.
Mutations in BMP4 or its receptors can lead to congenital disorders, such as orofacial clefts and heart defects.
Yes, there are ongoing trials exploring the use of BMP4 in regenerative medicine for conditions like osteoarthritis and tendon injuries.
Yes, some risks include excessive bone growth, swelling, and inflammation at the application site. These complications can be carefully managed by healthcare providers.
Yes, BMP4 can be used to aid in tissue regeneration in cosmetic procedures, such as in the reconstruction of facial bone defects or enhancement of soft tissue volume.
Customer Reviews (3)
Write a reviewThe BMP4 protein is a valuable resource for researchers due to its high quality and its ability to meet specific experimental needs.
the manufacturer's technical support team can offer prompt assistance in case any issues arise during the handling or application of the BMP4 protein.
The manufacturer's support can play a crucial role in assisting researchers throughout their trials.
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